VIP (Vasoactive Intestinal Peptide)
Also known as: Vasoactive Intestinal Peptide · VIP neuropeptide
A 28-amino acid neuropeptide naturally found throughout the nervous system and gastrointestinal tract. Acts as a potent vasodilator, immune modulator, and anti-inflammatory agent. Used in the Shoemaker CIRS/mold illness protocol and studied for pulmonary hypertension.
Mechanism of Action
VIP binds to VPAC1 and VPAC2 receptors throughout the body, activating adenylate cyclase to increase cAMP. It acts as a neurotransmitter, vasodilator, and immunomodulator — suppressing pro-inflammatory cytokines (TNF-α, IL-6) while upregulating anti-inflammatory mediators. Also stimulates secretin, glucagon, and insulin pathways.
Benefits
- Potent anti-inflammatory and immunomodulatory effects
- Reduces cytokine storms and chronic inflammation
- Studied for CIRS (Chronic Inflammatory Response Syndrome) treatment
- Pulmonary vasodilation (pulmonary hypertension research)
- Gut motility support and IBS research
- Neuroprotective properties
- Improves exercise tolerance and lung function
Side Effects & Risks
- Flushing and warmth at injection (transient vasodilation)
- Hypotension if dosed too rapidly
- Nausea
- Headache
- Limited long-term human data outside specific conditions
Where to Buy VIP (Vasoactive Intestinal Peptide)
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Storage & Reconstitution Guide
Storage Temperature
-20°C (lyophilized)
24 months (lyophilized), 28 days (reconstituted)
Reconstitution Solvent
Bacteriostatic water (BAC water)
Swirl gently — do not shake or vortex
Handling Notes
Protect lyophilized peptide from moisture and light. Once reconstituted, keep refrigerated. Discard if solution becomes cloudy or discolored. Use insulin syringe for precise dosing.
Step-by-Step Reconstitution
Gather supplies
BAC water, insulin syringe, alcohol swabs, vial
Disinfect tops
Swab rubber stoppers of both vials with alcohol
Draw BAC water
Pull desired mL of BAC water into syringe
Inject slowly
Inject BAC water down the side of the peptide vial, swirl gently to dissolve
Preclinical Research & Reviews1
Vasoactive intestinal peptide treatment for Shoemaker CIRS
VIP nasal spray significantly improved biomarkers and symptoms in CIRS (Chronic Inflammatory Response Syndrome) patients.
Survival Odds
2.0x higher (OR 2.0, 95% CI 1.0-3.9; p=0.035)
Respiratory Freedom
p=0.02
Molecular Structure
- CAS Number
- 37221-79-7
- PubChem CID
- 53314964
- Molecular Weight
- 3,326.8 Da
- Mol. Formula
- C147H237N43O43S
- Amino Acids
- 28-AA peptide
- Wikipedia
- View article
Research Protocol
- Dose Range
- 50–100 mcg
- Frequency
- 1-2x per day intranasal
- Cycle
- 30 days (CIRS protocol) or 4-8 weeks
- Half-Life
- 1-2 minutes
- Routes
- intranasalsubcutaneous injectionintravenous injection
- Notes
- Shoemaker CIRS protocol uses 50mcg per nostril 4x daily for 30 days. Start low to assess tolerance.
Legal & Regulatory Status
Sold for research purposes only. Not for human use. Laws vary by country.
Commonly Stacked With
View all peptide stacks →External Resources
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