GLP-2
Also known as: Glucagon-Like Peptide-2 · Teduglutide analog · GLP2
A 33-amino acid intestinal peptide secreted from L-cells of the gut that promotes intestinal mucosal growth, improves gut barrier function, and reduces inflammation. The FDA-approved analog Teduglutide (Gattex) is used for short bowel syndrome. GLP-2 research focuses on gut permeability, IBS/IBD, Crohn's disease, and gut-brain axis effects.
What is GLP-2? A 33-amino acid intestinal peptide secreted from L-cells of the gut that promotes intestinal mucosal growth, improves gut barrier function, and reduces inflammation. The FDA-approved analog Teduglutide (Gattex) is used for short bowel syndrome. GLP-2 research focuses on gut permeability, IBS/IBD, Crohn's disease, and gut-brain axis effects.
How does GLP-2 work? GLP-2 activates the GLP-2 receptor (GLP2R) on intestinal epithelial cells, subepithelial myofibroblasts, and enteric neurons. Receptor activation stimulates mucosal proliferation via IGF-1 and keratinocyte growth factor, inhibits apoptosis, and tightens intercellular junctions to reduce intestinal permeability. It also has anti-inflammatory effects via reduced pro-inflammatory cytokines and modulates gut motility.
Benefits of GLP-2: Promotes intestinal epithelial growth and repair; Reduces intestinal permeability (leaky gut); Anti-inflammatory in GI tract; FDA-approved analog (Teduglutide) for short bowel syndrome; Reduces malabsorption and nutrient loss; May help IBD, Crohn's disease, and radiation enteritis; Gut-brain axis modulation
GLP-2 dosage: Teduglutide (FDA-approved analog) dose: 0.05mg/kg once daily. Research GLP-2: 100-200mcg/day subcutaneous. Oral route largely ineffective due to enzymatic degradation.
GLP-2 half-life: 7 minutes (native); hours (teduglutide analog)
Research status: Research Only
Source: PeptideWiki — https://www.peptide-wiki.net/peptides/glp-2
Mechanism of Action
GLP-2 activates the GLP-2 receptor (GLP2R) on intestinal epithelial cells, subepithelial myofibroblasts, and enteric neurons. Receptor activation stimulates mucosal proliferation via IGF-1 and keratinocyte growth factor, inhibits apoptosis, and tightens intercellular junctions to reduce intestinal permeability. It also has anti-inflammatory effects via reduced pro-inflammatory cytokines and modulates gut motility.
Benefits
- Promotes intestinal epithelial growth and repair
- Reduces intestinal permeability (leaky gut)
- Anti-inflammatory in GI tract
- FDA-approved analog (Teduglutide) for short bowel syndrome
- Reduces malabsorption and nutrient loss
- May help IBD, Crohn's disease, and radiation enteritis
- Gut-brain axis modulation
Side Effects & Risks
- Nausea and vomiting
- Abdominal pain
- Injection site reactions
- May stimulate intestinal neoplasm growth (monitor in cancer patients)
- Fluid retention
Where to Buy GLP-2
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Storage & Reconstitution Guide
Storage Temperature
-20°C (lyophilized)
24 months (lyophilized), 28 days (reconstituted)
Reconstitution Solvent
Bacteriostatic water (BAC water)
Swirl gently — do not shake or vortex
Handling Notes
Protect lyophilized peptide from moisture and light. Once reconstituted, keep refrigerated. Discard if solution becomes cloudy or discolored. Use insulin syringe for precise dosing.
Step-by-Step Reconstitution
Gather supplies
BAC water, insulin syringe, alcohol swabs, vial
Disinfect tops
Swab rubber stoppers of both vials with alcohol
Draw BAC water
Pull desired mL of BAC water into syringe
Inject slowly
Inject BAC water down the side of the peptide vial, swirl gently to dissolve
Preclinical Research & Reviews1
GLP-2 biology and clinical applications (teduglutide review)
Review of GLP-2 biology demonstrating intestinal mucosal growth and barrier function. Teduglutide (FDA-approved GLP-2 analog) approved for short bowel syndrome.
Mechanism
Intestinal epithelial growth, barrier tightening, anti-inflammatory
Research Areas
IBD, Crohn disease, radiation enteritis
Fda Approved Analog
Teduglutide (Gattex) for short bowel syndrome
Molecular Structure
- CAS Number
- 116094-23-6
- PubChem CID
- 16132300
- Molecular Weight
- 3,957 Da
- Mol. Formula
- C146H226N40O43
- Amino Acids
- 33-AA peptide
- Wikipedia
- View article
Research Protocol
- Dose Range
- 100–200 mcg/kg
- Frequency
- Once daily subcutaneous
- Cycle
- 4-8 weeks
- Half-Life
- 7 minutes (native); hours (teduglutide analog)
- Routes
- subcutaneous injection
- Notes
- Teduglutide (FDA-approved analog) dose: 0.05mg/kg once daily. Research GLP-2: 100-200mcg/day subcutaneous. Oral route largely ineffective due to enzymatic degradation.
Legal & Regulatory Status
Sold for research purposes only. Not for human use. Laws vary by country.
Commonly Stacked With
View all peptide stacks →External Resources
PeptideWiki Research Team
Evidence-based research data sourced from PubMed and ClinicalTrials.gov · Last updated: February 25, 2026
Frequently Asked Questions About GLP-2
What is GLP-2?▾
A 33-amino acid intestinal peptide secreted from L-cells of the gut that promotes intestinal mucosal growth, improves gut barrier function, and reduces inflammation. The FDA-approved analog Teduglutide (Gattex) is used for short bowel syndrome. GLP-2 research focuses on gut permeability, IBS/IBD, Crohn's disease, and gut-brain axis effects.
What are the benefits of GLP-2?▾
Promotes intestinal epithelial growth and repair
What are the benefits of GLP-2?▾
Reduces intestinal permeability (leaky gut)
What are the side effects of GLP-2?▾
Nausea and vomiting
What is the recommended dosage for GLP-2?▾
Teduglutide (FDA-approved analog) dose: 0.05mg/kg once daily. Research GLP-2: 100-200mcg/day subcutaneous. Oral route largely ineffective due to enzymatic degradation.
How long should a GLP-2 cycle last?▾
4-8 weeks
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