KPV
Also known as: Alpha-MSH(11-13) · Lys-Pro-Val · KPV tripeptide
A naturally occurring tripeptide (Lys-Pro-Val) derived from the C-terminus of alpha-MSH. Anti-inflammatory, antimicrobial, and gut-protective without causing skin pigmentation. Highly studied for IBD, Crohn's disease, skin conditions, and wound healing.
What is KPV? A naturally occurring tripeptide (Lys-Pro-Val) derived from the C-terminus of alpha-MSH. Anti-inflammatory, antimicrobial, and gut-protective without causing skin pigmentation. Highly studied for IBD, Crohn's disease, skin conditions, and wound healing.
How does KPV work? KPV acts on melanocortin receptors and directly inhibits NF-κB signaling to suppress inflammatory cytokines (IL-1β, IL-6, TNF-α). Unlike full alpha-MSH, it has no pigmentation effects (no MC1R binding) but retains all anti-inflammatory and antimicrobial properties. It also restores gut barrier function.
Benefits of KPV: Potent anti-inflammatory (inhibits NF-κB); No pigmentation side effects; Gut barrier restoration and IBD research; Antimicrobial properties (Staphylococcus, Candida); Wound healing acceleration; Skin condition treatment (psoriasis, eczema); Effective orally and topically
KPV dosage: Oral capsules effective for gut. Injectable for systemic effects. Topical for skin. Often combined with BPC-157 for gut protocols.
KPV half-life: ~1 hour
Research status: Research Only
Source: PeptideWiki — https://www.peptide-wiki.net/peptides/kpv
Mechanism of Action
KPV acts on melanocortin receptors and directly inhibits NF-κB signaling to suppress inflammatory cytokines (IL-1β, IL-6, TNF-α). Unlike full alpha-MSH, it has no pigmentation effects (no MC1R binding) but retains all anti-inflammatory and antimicrobial properties. It also restores gut barrier function.
Benefits
- Potent anti-inflammatory (inhibits NF-κB)
- No pigmentation side effects
- Gut barrier restoration and IBD research
- Antimicrobial properties (Staphylococcus, Candida)
- Wound healing acceleration
- Skin condition treatment (psoriasis, eczema)
- Effective orally and topically
Side Effects & Risks
- Generally very well tolerated
- Minimal reported side effects
- Mild GI discomfort (rare)
Where to Buy KPV
4 options across 4 vendors · Sorted cheapest first · All include direct product link
From
$39.99
All links are affiliate links — PeptideWiki earns a commission at no extra cost to you. Coupon codes apply at checkout. Prices and availability may change. Always verify COA before purchasing.
Storage & Reconstitution Guide
Storage Temperature
-20°C lyophilized, 4°C reconstituted
24 months (lyophilized), 28 days (reconstituted)
Reconstitution Solvent
Bacteriostatic water (BAC water) or saline for oral
Swirl gently — do not shake or vortex
Handling Notes
Protect lyophilized peptide from moisture and light. Once reconstituted, keep refrigerated. Discard if solution becomes cloudy or discolored. Use insulin syringe for precise dosing.
Step-by-Step Reconstitution
Gather supplies
BAC water, insulin syringe, alcohol swabs, vial
Disinfect tops
Swab rubber stoppers of both vials with alcohol
Draw BAC water
Pull desired mL of BAC water into syringe
Inject slowly
Inject BAC water down the side of the peptide vial, swirl gently to dissolve
Preclinical Research & Reviews1
Alpha-MSH tripeptide analog KPV is a potent anti-inflammatory compound
KPV tripeptide demonstrated potent anti-inflammatory effects in intestinal epithelial cells and colitis models.
Research Protocol
- Dose Range
- 250–500 mcg
- Frequency
- 1-2x daily oral, topical, or injectable
- Cycle
- 4-8 weeks
- Half-Life
- ~1 hour
- Routes
- oraltopicalsubcutaneous injection
- Notes
- Oral capsules effective for gut. Injectable for systemic effects. Topical for skin. Often combined with BPC-157 for gut protocols.
Legal & Regulatory Status
Sold for research purposes only. Not for human use. Laws vary by country.
Commonly Stacked With
View all peptide stacks →External Resources
PeptideWiki Research Team
Evidence-based research data sourced from PubMed and ClinicalTrials.gov · Last updated: February 25, 2026
Frequently Asked Questions About KPV
What is KPV?▾
A naturally occurring tripeptide (Lys-Pro-Val) derived from the C-terminus of alpha-MSH. Anti-inflammatory, antimicrobial, and gut-protective without causing skin pigmentation. Highly studied for IBD, Crohn's disease, skin conditions, and wound healing.
What are the benefits of KPV?▾
Potent anti-inflammatory (inhibits NF-κB)
What are the benefits of KPV?▾
No pigmentation side effects
What are the side effects of KPV?▾
Generally very well tolerated
What is the recommended dosage for KPV?▾
Oral capsules effective for gut. Injectable for systemic effects. Topical for skin. Often combined with BPC-157 for gut protocols.
How long should a KPV cycle last?▾
4-8 weeks
More Healing & Recovery Peptides
View all Healing & Recovery peptides →Cardiogen
Heart peptide bioregulator
A tetrapeptide cardiac bioregulator from the Khavinson series targeting myocardial tissue. Normalizes myocardial cell function, reduces cardiac oxidative stress, and provides cardioprotection against ischemia and aging-related cardiac decline. Studied for heart failure, cardiomyopathy, and post-infarction recovery.
Cartalax
Cartilage peptide bioregulator
A cartilage and bone-targeting peptide bioregulator from the Khavinson series. Studied for arthritis, osteochondrosis, fracture recovery, and joint aging. Stimulates chondrocyte proliferation and collagen synthesis in cartilage tissue, supporting structural repair and maintenance of joint integrity.
ARA-290
Cibinetide
A synthetic 11-amino acid peptide that mimics the tissue-protective actions of erythropoietin without its erythropoietic effects. Highly effective for neuropathic pain and nerve repair.
Svetinorm
BioLiver
A liver-targeting tetrapeptide bioregulator. Normalizes hepatocyte function, reduces liver fibrosis, improves bile acid metabolism, and protects against hepatotoxicity. Studied for NAFLD, alcohol-related liver damage, hepatitis recovery, and liver aging.