Melanotan 2
Also known as: MT-2 · Melanotan II
A broader-acting melanocortin peptide that stimulates both melanin production and the sexual arousal pathway. Produces potent tanning effects and is also used for erectile dysfunction.
What is Melanotan 2? A broader-acting melanocortin peptide that stimulates both melanin production and the sexual arousal pathway. Produces potent tanning effects and is also used for erectile dysfunction.
How does Melanotan 2 work? Melanotan 2 activates multiple melanocortin receptors: MC1R for pigmentation, MC3R and MC4R for sexual arousal and appetite suppression.
Benefits of Melanotan 2: Strong melanin production and skin tanning; Libido enhancement; Appetite suppression; Erectile dysfunction support; Fat loss (modest)
Melanotan 2 dosage: Start with 250mcg to assess nausea tolerance. Higher doses not recommended.
Melanotan 2 half-life: 30-60 minutes
Research status: Research Only
Source: PeptideWiki — https://www.peptide-wiki.net/peptides/melanotan-2
Mechanism of Action
Melanotan 2 activates multiple melanocortin receptors: MC1R for pigmentation, MC3R and MC4R for sexual arousal and appetite suppression.
Amino Acid Sequence (7 AAs)
Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH
Benefits
- Strong melanin production and skin tanning
- Libido enhancement
- Appetite suppression
- Erectile dysfunction support
- Fat loss (modest)
Side Effects & Risks
- Nausea (significant)
- Spontaneous erections (males)
- Facial flushing
- Fatigue
- Yawning
- Potential kidney damage at high doses
Where to Buy Melanotan 2
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From
$29.99
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Storage & Reconstitution Guide
Storage Temperature
-20°C lyophilized, 4°C reconstituted
24 months (lyophilized), 28 days (reconstituted)
Reconstitution Solvent
Bacteriostatic water (BAC water)
Swirl gently — do not shake or vortex
Handling Notes
Protect lyophilized peptide from moisture and light. Once reconstituted, keep refrigerated. Discard if solution becomes cloudy or discolored. Use insulin syringe for precise dosing.
Step-by-Step Reconstitution
Gather supplies
BAC water, insulin syringe, alcohol swabs, vial
Disinfect tops
Swab rubber stoppers of both vials with alcohol
Draw BAC water
Pull desired mL of BAC water into syringe
Inject slowly
Inject BAC water down the side of the peptide vial, swirl gently to dissolve
Clinical Trials & Human Studies1 trial
Melanotan II for Erectile Dysfunction: Placebo-Controlled RCT
In 20 men with psychogenic erectile dysfunction, SC melanotan II (0.025 mg/kg) induced erections in 17/20 (85%) vs 3/20 (15%) placebo. Mean penile rigidity >80% for 38 min (MT-II) vs 3 min (placebo). Sexual desire increased: 17/20 (85%) vs 4/20 (20%).
Primary Outcome
Penile erection induction
p-value
<0.001
Erection Rate
85% (MT-II) vs 15% (placebo)
Adverse Events
Nausea 70%, yawning 45%, stretching 40%
Desire Increase
85% vs 20%
Rigidity Duration
38 min vs 3 min
Molecular Structure
- CAS Number
- 121062-08-6
- PubChem CID
- 92432
- Molecular Weight
- 1,024.2 Da
- Mol. Formula
- C50H69N15O9
- Amino Acids
- 7-AA peptide
- Wikipedia
- View article
Research Protocol
- Dose Range
- 250–500 mcg
- Frequency
- Daily loading, then 2-3x per week maintenance
- Cycle
- 4-8 weeks loading
- Half-Life
- 30-60 minutes
- Routes
- subcutaneous injectionintranasal
- Notes
- Start with 250mcg to assess nausea tolerance. Higher doses not recommended.
Legal & Regulatory Status
Sold for research purposes only. Not for human use. Laws vary by country.
Commonly Stacked With
View all peptide stacks →External Resources
PeptideWiki Research Team
Evidence-based research data sourced from PubMed and ClinicalTrials.gov · Last updated: February 25, 2026
Frequently Asked Questions About Melanotan 2
What is Melanotan 2?▾
A broader-acting melanocortin peptide that stimulates both melanin production and the sexual arousal pathway. Produces potent tanning effects and is also used for erectile dysfunction.
What are the benefits of Melanotan 2?▾
Strong melanin production and skin tanning
What are the benefits of Melanotan 2?▾
Libido enhancement
What are the side effects of Melanotan 2?▾
Nausea (significant)
What is the recommended dosage for Melanotan 2?▾
Start with 250mcg to assess nausea tolerance. Higher doses not recommended.
How long should a Melanotan 2 cycle last?▾
4-8 weeks loading