PT-141
Also known as: Bremelanotide · PT141 · Vyleesi
An FDA-approved melanocortin agonist for hypoactive sexual desire disorder (HSDD) in premenopausal women. Acts centrally via the CNS to increase sexual desire and arousal in both men and women.
What is PT-141? An FDA-approved melanocortin agonist for hypoactive sexual desire disorder (HSDD) in premenopausal women. Acts centrally via the CNS to increase sexual desire and arousal in both men and women.
How does PT-141 work? PT-141 activates MC3R and MC4R receptors in the hypothalamus and limbic system, increasing sexual desire through central nervous system mechanisms rather than vascular effects.
Benefits of PT-141: Increases sexual desire and arousal in men and women; FDA-approved for HSDD in premenopausal women; Treats erectile dysfunction through novel CNS mechanism; Works in individuals who do not respond to PDE5 inhibitors
PT-141 dosage: FDA-approved dose: 1.75mg subcutaneous. No more than once per 24 hours.
PT-141 half-life: 2 hours
Research status: FDA Approved
Source: PeptideWiki — https://www.peptide-wiki.net/peptides/pt-141
Mechanism of Action
PT-141 activates MC3R and MC4R receptors in the hypothalamus and limbic system, increasing sexual desire through central nervous system mechanisms rather than vascular effects.
Amino Acid Sequence (7 AAs)
Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH
Benefits
- Increases sexual desire and arousal in men and women
- FDA-approved for HSDD in premenopausal women
- Treats erectile dysfunction through novel CNS mechanism
- Works in individuals who do not respond to PDE5 inhibitors
Side Effects & Risks
- Nausea (most common)
- Flushing
- Headache
- Transient blood pressure increases
- Spontaneous erections (males)
Where to Buy PT-141
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From
$34.99
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Storage & Reconstitution Guide
Storage Temperature
-20°C lyophilized, 4°C reconstituted
24 months (lyophilized), 28 days (reconstituted)
Reconstitution Solvent
Bacteriostatic water (BAC water)
Swirl gently — do not shake or vortex
Handling Notes
Protect lyophilized peptide from moisture and light. Once reconstituted, keep refrigerated. Discard if solution becomes cloudy or discolored. Use insulin syringe for precise dosing.
Step-by-Step Reconstitution
Gather supplies
BAC water, insulin syringe, alcohol swabs, vial
Disinfect tops
Swab rubber stoppers of both vials with alcohol
Draw BAC water
Pull desired mL of BAC water into syringe
Inject slowly
Inject BAC water down the side of the peptide vial, swirl gently to dissolve
Clinical Trials & Human Studies2 trials
Bremelanotide for Female Hypoactive Sexual Desire Disorder
Bremelanotide (PT-141) significantly improved sexual desire in premenopausal women with HSDD.
RECONNECT Trials: Bremelanotide for Hypoactive Sexual Desire Disorder
Two Phase 3 RCTs (n=1,267 combined) in premenopausal women with HSDD. Both trials met co-primary endpoints: significant improvements in sexual desire (FSFI desire score) and distress (FSDS-DAO Item 13) vs placebo (p<0.05). Satisfying sexual events increased 0.7/month vs 0.4/month placebo.
Result
Both endpoints met in both trials (p<0.05)
Responders
25% vs 17% placebo showed meaningful improvement
Primary Endpoints
FSFI desire domain score + FSDS-DAO Item 13 distress score
Satisfying Events
+0.7/month (bremelanotide) vs +0.4/month (placebo)
Molecular Structure
- CAS Number
- 189691-06-3
- PubChem CID
- 9941379
- Molecular Weight
- 1,025.2 Da
- Mol. Formula
- C50H68N14O10
- Amino Acids
- 7-AA peptide
- Wikipedia
- View article
Research Protocol
- Dose Range
- 1–2 mg
- Frequency
- As needed, 45-90 minutes before sexual activity
- Cycle
- As needed
- Half-Life
- 2 hours
- Routes
- subcutaneous injectionintranasal
- Notes
- FDA-approved dose: 1.75mg subcutaneous. No more than once per 24 hours.
Legal & Regulatory Status
Sold for research purposes only. Not for human use. Laws vary by country.
Commonly Stacked With
View all peptide stacks →External Resources
PeptideWiki Research Team
Evidence-based research data sourced from PubMed and ClinicalTrials.gov · Last updated: February 25, 2026
Frequently Asked Questions About PT-141
What is PT-141?▾
An FDA-approved melanocortin agonist for hypoactive sexual desire disorder (HSDD) in premenopausal women. Acts centrally via the CNS to increase sexual desire and arousal in both men and women.
What are the benefits of PT-141?▾
Increases sexual desire and arousal in men and women
What are the benefits of PT-141?▾
FDA-approved for HSDD in premenopausal women
What are the side effects of PT-141?▾
Nausea (most common)
What is the recommended dosage for PT-141?▾
FDA-approved dose: 1.75mg subcutaneous. No more than once per 24 hours.
How long should a PT-141 cycle last?▾
As needed
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