HMG
Also known as: Human Menopausal Gonadotropin · Menopur · Menogon
A urinary-derived combination of LH and FSH used clinically for fertility treatment and in TRT protocols for testicular stimulation and spermatogenesis support.
What is HMG? A urinary-derived combination of LH and FSH used clinically for fertility treatment and in TRT protocols for testicular stimulation and spermatogenesis support.
How does HMG work? HMG contains both FSH and LH. LH stimulates Leydig cells to produce testosterone while FSH supports spermatogenesis and Sertoli cell function.
Benefits of HMG: Stimulates both testosterone production and spermatogenesis; Fertility support in men on TRT; Testicular volume maintenance; Combined LH and FSH activity; Superior to hCG for sperm production
HMG dosage: Used in fertility medicine and TRT protocols. Requires medical supervision.
HMG half-life: 24-36 hours
Research status: Prescription
Source: PeptideWiki — https://www.peptide-wiki.net/peptides/hmg
Mechanism of Action
HMG contains both FSH and LH. LH stimulates Leydig cells to produce testosterone while FSH supports spermatogenesis and Sertoli cell function.
Benefits
- Stimulates both testosterone production and spermatogenesis
- Fertility support in men on TRT
- Testicular volume maintenance
- Combined LH and FSH activity
- Superior to hCG for sperm production
Side Effects & Risks
- Injection site reactions
- Gynecomastia risk
- Ovarian hyperstimulation in women
- Mood changes
Where to Buy HMG
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From
$39.99
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Storage & Reconstitution Guide
Storage Temperature
-20°C (lyophilized)
24 months (lyophilized), 28 days (reconstituted)
Reconstitution Solvent
Bacteriostatic water (BAC water)
Swirl gently — do not shake or vortex
Handling Notes
Protect lyophilized peptide from moisture and light. Once reconstituted, keep refrigerated. Discard if solution becomes cloudy or discolored. Use insulin syringe for precise dosing.
Step-by-Step Reconstitution
Gather supplies
BAC water, insulin syringe, alcohol swabs, vial
Disinfect tops
Swab rubber stoppers of both vials with alcohol
Draw BAC water
Pull desired mL of BAC water into syringe
Inject slowly
Inject BAC water down the side of the peptide vial, swirl gently to dissolve
Research Protocol
- Dose Range
- 75–150 IU
- Frequency
- 3x weekly subcutaneous injection
- Cycle
- 4-12 weeks
- Half-Life
- 24-36 hours
- Routes
- subcutaneous injectionintramuscular injection
- Notes
- Used in fertility medicine and TRT protocols. Requires medical supervision.
Legal & Regulatory Status
Sold for research purposes only. Not for human use. Laws vary by country.
Commonly Stacked With
View all peptide stacks →External Resources
PeptideWiki Research Team
Evidence-based research data sourced from PubMed and ClinicalTrials.gov · Last updated: February 25, 2026
Frequently Asked Questions About HMG
What is HMG?▾
A urinary-derived combination of LH and FSH used clinically for fertility treatment and in TRT protocols for testicular stimulation and spermatogenesis support.
What are the benefits of HMG?▾
Stimulates both testosterone production and spermatogenesis
What are the benefits of HMG?▾
Fertility support in men on TRT
What are the side effects of HMG?▾
Injection site reactions
What is the recommended dosage for HMG?▾
Used in fertility medicine and TRT protocols. Requires medical supervision.
How long should a HMG cycle last?▾
4-12 weeks
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