Kisspeptin-10
Also known as: Metastin 45-54 · Kisspeptin 10 · KP-10
A 10-amino acid neuropeptide that acts as the master regulator of the reproductive hormonal axis by stimulating GnRH release. Supports testosterone, libido, fertility, and sexual health.
Mechanism of Action
Kisspeptin-10 binds to KISS1R receptors on GnRH neurons in the hypothalamus, triggering pulsatile GnRH release which drives LH, FSH, testosterone, and estrogen production.
Amino Acid Sequence (10 AAs)
Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂
Benefits
- Stimulates GnRH and downstream testosterone/estrogen
- Increases sexual arousal and motivation
- Supports fertility
- Improves hormonal balance
- Used in TRT protocols
Side Effects & Risks
- Mild nausea
- Headache
- Flushing
Storage & Reconstitution Guide
Storage Temperature
-20°C lyophilized, 4°C reconstituted
24 months (lyophilized), 28 days (reconstituted)
Reconstitution Solvent
Bacteriostatic water (BAC water)
Swirl gently — do not shake or vortex
Handling Notes
Protect lyophilized peptide from moisture and light. Once reconstituted, keep refrigerated. Discard if solution becomes cloudy or discolored. Use insulin syringe for precise dosing.
Step-by-Step Reconstitution
Gather supplies
BAC water, insulin syringe, alcohol swabs, vial
Disinfect tops
Swab rubber stoppers of both vials with alcohol
Draw BAC water
Pull desired mL of BAC water into syringe
Inject slowly
Inject BAC water down the side of the peptide vial, swirl gently to dissolve
Molecular Structure
- CAS Number
- 374675-21-5
- PubChem CID
- 25240297
- Molecular Weight
- 1,302.44 Da
- Mol. Formula
- C63H87N15O14
- Amino Acids
- 10-AA peptide
- Wikipedia
- View article
Research Protocol
- Dose Range
- 10–100 mcg
- Frequency
- Pulse dosing 2-3x weekly
- Cycle
- 4-8 weeks
- Half-Life
- 28 minutes
- Routes
- subcutaneous injectionintranasal
- Notes
- Continuous administration can desensitize KISS1R. Use pulsatile dosing protocol.
Legal & Regulatory Status
Sold for research purposes only. Not for human use. Laws vary by country.
Commonly Stacked With
View all peptide stacks →External Resources
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