Gonadorelin
Also known as: GnRH · Gonadotropin-Releasing Hormone · LHRH · Factrel
A synthetic form of endogenous GnRH that stimulates the pituitary to release LH and FSH. Widely used in TRT protocols to maintain testicular size and function.
Mechanism of Action
Gonadorelin binds GnRH receptors on pituitary gonadotroph cells, stimulating pulsatile release of LH and FSH, which drives testosterone production and spermatogenesis.
Amino Acid Sequence (10 AAs)
pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH₂
Benefits
- Maintains testicular volume during TRT
- Prevents secondary hypogonadism
- Preserves fertility during testosterone use
- Diagnostic tool for GnRH deficiency
- Supports post-cycle recovery
Side Effects & Risks
- Injection site reactions
- Flushing
- Nausea
- Headache
- Tachyphylaxis with continuous administration
Where to Buy Gonadorelin
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From
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Storage & Reconstitution Guide
Storage Temperature
-20°C lyophilized, 4°C reconstituted
24 months (lyophilized), 28 days (reconstituted)
Reconstitution Solvent
Bacteriostatic water (BAC water)
Swirl gently — do not shake or vortex
Handling Notes
Protect lyophilized peptide from moisture and light. Once reconstituted, keep refrigerated. Discard if solution becomes cloudy or discolored. Use insulin syringe for precise dosing.
Step-by-Step Reconstitution
Gather supplies
BAC water, insulin syringe, alcohol swabs, vial
Disinfect tops
Swab rubber stoppers of both vials with alcohol
Draw BAC water
Pull desired mL of BAC water into syringe
Inject slowly
Inject BAC water down the side of the peptide vial, swirl gently to dissolve
Molecular Structure
- CAS Number
- 33515-09-2
- PubChem CID
- 638793
- Molecular Weight
- 1,182.3 Da
- Mol. Formula
- C55H75N17O13
- Amino Acids
- 10-AA peptide
- Wikipedia
- View article
Research Protocol
- Dose Range
- 100–250 mcg
- Frequency
- 2-3x weekly, subcutaneous injection
- Cycle
- Concurrent with TRT
- Half-Life
- 2-4 minutes
- Routes
- subcutaneous injection
- Notes
- Must be dosed pulsatilely (not continuously) to avoid desensitization.
Legal & Regulatory Status
Sold for research purposes only. Not for human use. Laws vary by country.
Commonly Stacked With
View all peptide stacks →External Resources
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