Enclomiphene
Also known as: Trans-clomiphene · Androxal · Enclomiphene citrate
The active trans-isomer of clomiphene citrate that acts as a selective estrogen receptor modulator (SERM). Blocks pituitary estrogen receptors to increase LH/FSH production and downstream testosterone synthesis. Studied for male hypogonadism as an alternative to TRT that preserves fertility and natural testosterone production.
Mechanism of Action
Enclomiphene blocks estrogen receptors in the hypothalamus and pituitary, preventing negative feedback inhibition of GnRH, LH, and FSH secretion. This drives increased LH/FSH production, stimulating Leydig cells to produce more testosterone. Unlike exogenous testosterone, enclomiphene restores T through the natural HPG axis, preserving testicular function and fertility.
Benefits
- Restores testosterone through natural HPG axis (preserves fertility)
- Alternative to TRT for hypogonadism
- Increases LH, FSH, and testosterone simultaneously
- Preserves testicular size and sperm production
- Once-daily oral administration
- Does not suppress natural testosterone production long-term
- May improve mood, energy, and libido
Side Effects & Risks
- Mild estrogenic side effects possible (cis-isomer impurity)
- Visual disturbances (rare, clomiphene class)
- Hot flashes
- Mood changes in some users
Where to Buy Enclomiphene
2 options across 2 vendors · Sorted cheapest first · All include direct product link
From
$69.99
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Storage & Reconstitution Guide
Storage Temperature
-20°C (lyophilized)
24 months (lyophilized), 28 days (reconstituted)
Reconstitution Solvent
Bacteriostatic water (BAC water)
Swirl gently — do not shake or vortex
Handling Notes
Protect lyophilized peptide from moisture and light. Once reconstituted, keep refrigerated. Discard if solution becomes cloudy or discolored. Use insulin syringe for precise dosing.
Step-by-Step Reconstitution
Gather supplies
BAC water, insulin syringe, alcohol swabs, vial
Disinfect tops
Swab rubber stoppers of both vials with alcohol
Draw BAC water
Pull desired mL of BAC water into syringe
Inject slowly
Inject BAC water down the side of the peptide vial, swirl gently to dissolve
Research Protocol
- Dose Range
- 12.5–25 mg
- Frequency
- Once daily oral
- Cycle
- 12-24 weeks
- Routes
- oral
- Notes
- Phase 3 dose: 12.5-25mg/day. Common research protocol: 12.5-25mg/day oral for 12 weeks. Monitor testosterone, LH, FSH, estradiol.
Legal & Regulatory Status
Sold for research purposes only. Not for human use. Laws vary by country.
Commonly Stacked With
View all peptide stacks →External Resources
Chemical Properties
- CAS Number
- 15690-57-0
- Mol. Weight
- 405.9 Da
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