Enclomiphene
Also known as: Trans-clomiphene · Androxal · Enclomiphene citrate
The active trans-isomer of clomiphene citrate that acts as a selective estrogen receptor modulator (SERM). Blocks pituitary estrogen receptors to increase LH/FSH production and downstream testosterone synthesis. Studied for male hypogonadism as an alternative to TRT that preserves fertility and natural testosterone production.
What is Enclomiphene? The active trans-isomer of clomiphene citrate that acts as a selective estrogen receptor modulator (SERM). Blocks pituitary estrogen receptors to increase LH/FSH production and downstream testosterone synthesis. Studied for male hypogonadism as an alternative to TRT that preserves fertility and natural testosterone production.
How does Enclomiphene work? Enclomiphene blocks estrogen receptors in the hypothalamus and pituitary, preventing negative feedback inhibition of GnRH, LH, and FSH secretion. This drives increased LH/FSH production, stimulating Leydig cells to produce more testosterone. Unlike exogenous testosterone, enclomiphene restores T through the natural HPG axis, preserving testicular function and fertility.
Benefits of Enclomiphene: Restores testosterone through natural HPG axis (preserves fertility); Alternative to TRT for hypogonadism; Increases LH, FSH, and testosterone simultaneously; Preserves testicular size and sperm production; Once-daily oral administration; Does not suppress natural testosterone production long-term; May improve mood, energy, and libido
Enclomiphene dosage: Phase 3 dose: 12.5-25mg/day. Common research protocol: 12.5-25mg/day oral for 12 weeks. Monitor testosterone, LH, FSH, estradiol.
Research status: Research Only
Source: PeptideWiki — https://www.peptide-wiki.net/peptides/enclomiphene
Mechanism of Action
Enclomiphene blocks estrogen receptors in the hypothalamus and pituitary, preventing negative feedback inhibition of GnRH, LH, and FSH secretion. This drives increased LH/FSH production, stimulating Leydig cells to produce more testosterone. Unlike exogenous testosterone, enclomiphene restores T through the natural HPG axis, preserving testicular function and fertility.
Benefits
- Restores testosterone through natural HPG axis (preserves fertility)
- Alternative to TRT for hypogonadism
- Increases LH, FSH, and testosterone simultaneously
- Preserves testicular size and sperm production
- Once-daily oral administration
- Does not suppress natural testosterone production long-term
- May improve mood, energy, and libido
Side Effects & Risks
- Mild estrogenic side effects possible (cis-isomer impurity)
- Visual disturbances (rare, clomiphene class)
- Hot flashes
- Mood changes in some users
Where to Buy Enclomiphene
2 options across 2 vendors · Sorted cheapest first · All include direct product link
From
$69.99
All links are affiliate links — PeptideWiki earns a commission at no extra cost to you. Coupon codes apply at checkout. Prices and availability may change. Always verify COA before purchasing.
Storage & Reconstitution Guide
Storage Temperature
-20°C (lyophilized)
24 months (lyophilized), 28 days (reconstituted)
Reconstitution Solvent
Bacteriostatic water (BAC water)
Swirl gently — do not shake or vortex
Handling Notes
Protect lyophilized peptide from moisture and light. Once reconstituted, keep refrigerated. Discard if solution becomes cloudy or discolored. Use insulin syringe for precise dosing.
Step-by-Step Reconstitution
Gather supplies
BAC water, insulin syringe, alcohol swabs, vial
Disinfect tops
Swab rubber stoppers of both vials with alcohol
Draw BAC water
Pull desired mL of BAC water into syringe
Inject slowly
Inject BAC water down the side of the peptide vial, swirl gently to dissolve
Research Protocol
- Dose Range
- 12.5–25 mg
- Frequency
- Once daily oral
- Cycle
- 12-24 weeks
- Routes
- oral
- Notes
- Phase 3 dose: 12.5-25mg/day. Common research protocol: 12.5-25mg/day oral for 12 weeks. Monitor testosterone, LH, FSH, estradiol.
Legal & Regulatory Status
Sold for research purposes only. Not for human use. Laws vary by country.
Commonly Stacked With
View all peptide stacks →External Resources
Chemical Properties
- CAS Number
- 15690-57-0
- Mol. Weight
- 405.9 Da
PeptideWiki Research Team
Evidence-based research data sourced from PubMed and ClinicalTrials.gov · Last updated: February 25, 2026
Frequently Asked Questions About Enclomiphene
What is Enclomiphene?▾
The active trans-isomer of clomiphene citrate that acts as a selective estrogen receptor modulator (SERM). Blocks pituitary estrogen receptors to increase LH/FSH production and downstream testosterone synthesis. Studied for male hypogonadism as an alternative to TRT that preserves fertility and natural testosterone production.
What are the benefits of Enclomiphene?▾
Restores testosterone through natural HPG axis (preserves fertility)
What are the benefits of Enclomiphene?▾
Alternative to TRT for hypogonadism
What are the side effects of Enclomiphene?▾
Mild estrogenic side effects possible (cis-isomer impurity)
What is the recommended dosage for Enclomiphene?▾
Phase 3 dose: 12.5-25mg/day. Common research protocol: 12.5-25mg/day oral for 12 weeks. Monitor testosterone, LH, FSH, estradiol.
How long should a Enclomiphene cycle last?▾
12-24 weeks
More Sexual Health Peptides
View all Sexual Health peptides →Testagen
Testes peptide bioregulator
A tetrapeptide (Lys-Glu-Asp-Glu estimated) testes-targeting bioregulator from the Khavinson series. Normalizes Leydig cell function, testosterone synthesis, and testicular morphology. Used in male reproductive aging, hypogonadism research, and testosterone support protocols.
Ovagen
Ovarian peptide bioregulator
A peptide bioregulator targeting ovarian tissue from the Khavinson series. Studied for female reproductive aging, premature ovarian insufficiency, menopause symptom management, and ovarian reserve support. Normalizes follicular cell function and ovarian hormone synthesis.
HMG
Human Menopausal Gonadotropin
A urinary-derived combination of LH and FSH used clinically for fertility treatment and in TRT protocols for testicular stimulation and spermatogenesis support.
PT-141
Bremelanotide
An FDA-approved melanocortin agonist for hypoactive sexual desire disorder (HSDD) in premenopausal women. Acts centrally via the CNS to increase sexual desire and arousal in both men and women.