Retatrutide
Also known as: LY3437943
An emerging triple agonist targeting GLP-1, GIP, and glucagon receptors simultaneously. Phase 3 clinical trials show unprecedented weight loss of up to 24% body weight.
What is Retatrutide? An emerging triple agonist targeting GLP-1, GIP, and glucagon receptors simultaneously. Phase 3 clinical trials show unprecedented weight loss of up to 24% body weight.
How does Retatrutide work? Retatrutide acts simultaneously on GLP-1 (appetite suppression), GIP (incretin effect), and glucagon (energy expenditure) receptors, creating synergistic metabolic effects.
Benefits of Retatrutide: Up to 24% body weight reduction in Phase 2 trials; Triple receptor agonism; Superior to tirzepatide in early comparisons; Significant improvements in metabolic biomarkers; Weekly dosing
Retatrutide dosage: Not yet approved - Phase 3 clinical trials ongoing.
Research status: Clinical Trials
Source: PeptideWiki — https://www.peptide-wiki.net/peptides/retatrutide
Mechanism of Action
Retatrutide acts simultaneously on GLP-1 (appetite suppression), GIP (incretin effect), and glucagon (energy expenditure) receptors, creating synergistic metabolic effects.
Benefits
- Up to 24% body weight reduction in Phase 2 trials
- Triple receptor agonism
- Superior to tirzepatide in early comparisons
- Significant improvements in metabolic biomarkers
- Weekly dosing
Side Effects & Risks
- Nausea, vomiting, diarrhea
- Constipation
- Decreased appetite
- Currently only clinical trial data
Where to Buy Retatrutide
4 options across 3 vendors · Sorted cheapest first · All include direct product link
From
$78.00
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Storage & Reconstitution Guide
Storage Temperature
-20°C lyophilized, 4°C or room temp reconstituted
24 months (lyophilized), 28 days (reconstituted)
Reconstitution Solvent
Bacteriostatic water (BAC water)
Swirl gently — do not shake or vortex
Handling Notes
Protect lyophilized peptide from moisture and light. Once reconstituted, keep refrigerated. Discard if solution becomes cloudy or discolored. Use insulin syringe for precise dosing.
Step-by-Step Reconstitution
Gather supplies
BAC water, insulin syringe, alcohol swabs, vial
Disinfect tops
Swab rubber stoppers of both vials with alcohol
Draw BAC water
Pull desired mL of BAC water into syringe
Inject slowly
Inject BAC water down the side of the peptide vial, swirl gently to dissolve
Research Protocol
- Dose Range
- 1–12 mg
- Frequency
- Once weekly subcutaneous injection
- Cycle
- Ongoing / chronic
- Routes
- subcutaneous injection
- Notes
- Not yet approved - Phase 3 clinical trials ongoing.
Legal & Regulatory Status
Sold for research purposes only. Not for human use. Laws vary by country.
External Resources
PeptideWiki Research Team
Evidence-based research data sourced from PubMed and ClinicalTrials.gov · Last updated: February 25, 2026
Frequently Asked Questions About Retatrutide
What is Retatrutide?▾
An emerging triple agonist targeting GLP-1, GIP, and glucagon receptors simultaneously. Phase 3 clinical trials show unprecedented weight loss of up to 24% body weight.
What are the benefits of Retatrutide?▾
Up to 24% body weight reduction in Phase 2 trials
What are the benefits of Retatrutide?▾
Triple receptor agonism
What are the side effects of Retatrutide?▾
Nausea, vomiting, diarrhea
What is the recommended dosage for Retatrutide?▾
Not yet approved - Phase 3 clinical trials ongoing.
How long should a Retatrutide cycle last?▾
Ongoing / chronic
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