Cagrilintide
Also known as: AM833 · Long-acting amylin analog
A long-acting amylin analog being co-developed with semaglutide (as CagriSema) for obesity. Amylin signals satiety to the brain independently of GLP-1, making the combination synergistic for weight loss.
Mechanism of Action
Cagrilintide activates amylin (calcitonin family) receptors in the brainstem and hypothalamus, signaling satiety and reducing food intake. When combined with semaglutide (CagriSema), the dual satiety mechanism produced 25.1% weight loss in Phase 3 trials — approaching the results of bariatric surgery.
Amino Acid Sequence (37 AAs)
Modified 37-AA amylin backbone with fatty acid chain
Benefits
- Signals satiety via amylin pathway — distinct from GLP-1
- Combined with semaglutide: 25.1% weight loss (Phase 3)
- Reduces food intake and increases feeling of fullness
- Slows gastric emptying complementary to GLP-1
- Potential for superior weight loss vs. tirzepatide
Side Effects & Risks
- Nausea (especially when combined with semaglutide)
- Vomiting
- Constipation
- Injection site reactions
- Currently only in clinical trials
Where to Buy Cagrilintide
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Storage & Reconstitution Guide
Storage Temperature
-20°C lyophilized, 4°C reconstituted
24 months (lyophilized), 28 days (reconstituted)
Reconstitution Solvent
Bacteriostatic water (BAC water)
Swirl gently — do not shake or vortex
Handling Notes
Protect lyophilized peptide from moisture and light. Once reconstituted, keep refrigerated. Discard if solution becomes cloudy or discolored. Use insulin syringe for precise dosing.
Step-by-Step Reconstitution
Gather supplies
BAC water, insulin syringe, alcohol swabs, vial
Disinfect tops
Swab rubber stoppers of both vials with alcohol
Draw BAC water
Pull desired mL of BAC water into syringe
Inject slowly
Inject BAC water down the side of the peptide vial, swirl gently to dissolve
Clinical Trials & Human Studies2 trials
Cagrilintide combined with semaglutide for obesity treatment (CagriSema)
CagriSema (cagrilintide 2.4mg + semaglutide 2.4mg) produced 25.1% weight reduction in Phase 3 REDEFINE 1 trial.
Phase 2: Cagrilintide for Obesity Weight Loss
Dose-escalation RCT in 706 adults with overweight/obesity. Cagrilintide 4.5mg/week: -10.8% weight loss vs -3.0% placebo at 26 weeks (treatment difference -7.8%, 95% CI -9.2 to -6.4; p<0.001). Superior to liraglutide 3mg: -10.8% vs -9.0% (p=0.03).
Primary Outcome
Weight change from baseline at 26 weeks
95% CI
-9.2 to -6.4
p-value
<0.001
Placebo
-3.0%
Vs Liraglutide
-10.8% vs -9.0% (p=0.03)
Cagrilintide 4.5mg
-10.8%
Treatment Difference
-7.8%
Research Protocol
- Dose Range
- 0.3–2.4 mg
- Frequency
- Once weekly subcutaneous injection
- Cycle
- Ongoing / chronic
- Half-Life
- ~7 days
- Routes
- subcutaneous injection
- Notes
- Phase 3 trials use cagrilintide 2.4mg + semaglutide 2.4mg (CagriSema). Stand-alone dose being established.
Legal & Regulatory Status
Sold for research purposes only. Not for human use. Laws vary by country.
Commonly Stacked With
View all peptide stacks →External Resources
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