Cortagen
Also known as: Cerebral cortex peptide bioregulator · CNS tetrapeptide
A peptide bioregulator targeting the cerebral cortex and CNS from the Khavinson series. Normalizes cortical neuron function, reduces age-related neurodegeneration, and improves cognitive function. Particularly studied for age-associated cognitive decline, vascular dementia, and post-stroke recovery.
What is Cortagen? A peptide bioregulator targeting the cerebral cortex and CNS from the Khavinson series. Normalizes cortical neuron function, reduces age-related neurodegeneration, and improves cognitive function. Particularly studied for age-associated cognitive decline, vascular dementia, and post-stroke recovery.
How does Cortagen work? Cortagen targets cortical neuron nuclei and regulates expression of neuroprotective and neurotrophic genes. It reduces neuronal apoptosis under oxidative and ischemic stress, promotes synaptic plasticity, and normalizes neurotransmitter synthesis. Distinct from Pinealon (which targets pineal and circadian systems) in its direct cortical focus.
Benefits of Cortagen: Normalizes cortical neuron function; Reduces age-related cognitive decline; Neuroprotection under oxidative/ischemic stress; Post-stroke recovery support; Improves vascular dementia symptoms in Russian studies; Synaptic plasticity enhancement; Anti-aging effects in CNS
Cortagen dosage: Standard Khavinson protocol: 1-2mg/day for 10 days, 1-2x per year. Often combined with Semax or Pinealon.
Research status: Research Only
Source: PeptideWiki — https://www.peptide-wiki.net/peptides/cortagen
Mechanism of Action
Cortagen targets cortical neuron nuclei and regulates expression of neuroprotective and neurotrophic genes. It reduces neuronal apoptosis under oxidative and ischemic stress, promotes synaptic plasticity, and normalizes neurotransmitter synthesis. Distinct from Pinealon (which targets pineal and circadian systems) in its direct cortical focus.
Benefits
- Normalizes cortical neuron function
- Reduces age-related cognitive decline
- Neuroprotection under oxidative/ischemic stress
- Post-stroke recovery support
- Improves vascular dementia symptoms in Russian studies
- Synaptic plasticity enhancement
- Anti-aging effects in CNS
Side Effects & Risks
- Generally well tolerated
- Headache possible during initial use
- Limited standalone Western clinical data
Where to Buy Cortagen
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Storage & Reconstitution Guide
Storage Temperature
-20°C (lyophilized)
24 months (lyophilized), 28 days (reconstituted)
Reconstitution Solvent
Bacteriostatic water (BAC water)
Swirl gently — do not shake or vortex
Handling Notes
Protect lyophilized peptide from moisture and light. Once reconstituted, keep refrigerated. Discard if solution becomes cloudy or discolored. Use insulin syringe for precise dosing.
Step-by-Step Reconstitution
Gather supplies
BAC water, insulin syringe, alcohol swabs, vial
Disinfect tops
Swab rubber stoppers of both vials with alcohol
Draw BAC water
Pull desired mL of BAC water into syringe
Inject slowly
Inject BAC water down the side of the peptide vial, swirl gently to dissolve
Research Protocol
- Dose Range
- 1–2 mg
- Frequency
- Daily for 10-day courses
- Cycle
- 10-day courses, 1-2x per year
- Routes
- subcutaneous injection
- Notes
- Standard Khavinson protocol: 1-2mg/day for 10 days, 1-2x per year. Often combined with Semax or Pinealon.
Legal & Regulatory Status
Sold for research purposes only. Not for human use. Laws vary by country.
Commonly Stacked With
View all peptide stacks →External Resources
Chemical Properties
- Mol. Weight
- ~460 Da
PeptideWiki Research Team
Evidence-based research data sourced from PubMed and ClinicalTrials.gov · Last updated: February 25, 2026
Frequently Asked Questions About Cortagen
What is Cortagen?▾
A peptide bioregulator targeting the cerebral cortex and CNS from the Khavinson series. Normalizes cortical neuron function, reduces age-related neurodegeneration, and improves cognitive function. Particularly studied for age-associated cognitive decline, vascular dementia, and post-stroke recovery.
What are the benefits of Cortagen?▾
Normalizes cortical neuron function
What are the benefits of Cortagen?▾
Reduces age-related cognitive decline
What are the side effects of Cortagen?▾
Generally well tolerated
What is the recommended dosage for Cortagen?▾
Standard Khavinson protocol: 1-2mg/day for 10 days, 1-2x per year. Often combined with Semax or Pinealon.
How long should a Cortagen cycle last?▾
10-day courses, 1-2x per year
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