Pinealon
Also known as: EDR tetrapeptide · Glu-Asp-Arg · Pineal peptide bioregulator
A synthetic tripeptide (Glu-Asp-Arg) from the Khavinson peptide bioregulator series targeting the brain and pineal gland. Reduces neuronal apoptosis, improves cognitive function in aging models, and normalizes circadian rhythm disruption. Distinct from Epithalon despite also targeting the pineal gland.
What is Pinealon? A synthetic tripeptide (Glu-Asp-Arg) from the Khavinson peptide bioregulator series targeting the brain and pineal gland. Reduces neuronal apoptosis, improves cognitive function in aging models, and normalizes circadian rhythm disruption. Distinct from Epithalon despite also targeting the pineal gland.
How does Pinealon work? Pinealon is an organ-specific peptide bioregulator that binds to DNA regions in pineal and cortical neurons, regulating transcription of genes involved in neuronal survival and circadian clock function. Unlike Epithalon which primarily activates telomerase, Pinealon directly reduces caspase-3-mediated apoptosis and upregulates neuroprotective proteins in brain tissue, with particular efficacy under hypoxic conditions.
Benefits of Pinealon: Reduces neuronal apoptosis under ischemic/hypoxic conditions; Improves cognitive function in aging models; Normalizes disrupted circadian rhythms; Neuroprotection against oxidative stress; Anti-aging effects in brain tissue; Improves sleep quality; Synergistic with Epithalon for comprehensive anti-aging
Pinealon dosage: Typical cycle: 10-day courses 2-3x per year. Often combined with Epithalon. Evening dosing aligns with pineal/circadian effects.
Research status: Research Only
Source: PeptideWiki — https://www.peptide-wiki.net/peptides/pinealon
Mechanism of Action
Pinealon is an organ-specific peptide bioregulator that binds to DNA regions in pineal and cortical neurons, regulating transcription of genes involved in neuronal survival and circadian clock function. Unlike Epithalon which primarily activates telomerase, Pinealon directly reduces caspase-3-mediated apoptosis and upregulates neuroprotective proteins in brain tissue, with particular efficacy under hypoxic conditions.
Benefits
- Reduces neuronal apoptosis under ischemic/hypoxic conditions
- Improves cognitive function in aging models
- Normalizes disrupted circadian rhythms
- Neuroprotection against oxidative stress
- Anti-aging effects in brain tissue
- Improves sleep quality
- Synergistic with Epithalon for comprehensive anti-aging
Side Effects & Risks
- Generally well tolerated
- Limited standalone clinical data
- Some users report vivid dreams
Where to Buy Pinealon
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From
$55.00
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Storage & Reconstitution Guide
Storage Temperature
-20°C (lyophilized)
24 months (lyophilized), 28 days (reconstituted)
Reconstitution Solvent
Bacteriostatic water (BAC water)
Swirl gently — do not shake or vortex
Handling Notes
Protect lyophilized peptide from moisture and light. Once reconstituted, keep refrigerated. Discard if solution becomes cloudy or discolored. Use insulin syringe for precise dosing.
Step-by-Step Reconstitution
Gather supplies
BAC water, insulin syringe, alcohol swabs, vial
Disinfect tops
Swab rubber stoppers of both vials with alcohol
Draw BAC water
Pull desired mL of BAC water into syringe
Inject slowly
Inject BAC water down the side of the peptide vial, swirl gently to dissolve
Research Protocol
- Dose Range
- 5–10 mg
- Frequency
- Once daily, evening preferred
- Cycle
- 10 days per course, 2-3x per year
- Routes
- subcutaneous injectionintranasal
- Notes
- Typical cycle: 10-day courses 2-3x per year. Often combined with Epithalon. Evening dosing aligns with pineal/circadian effects.
Legal & Regulatory Status
Sold for research purposes only. Not for human use. Laws vary by country.
Commonly Stacked With
View all peptide stacks →External Resources
Chemical Properties
- CAS Number
- 1448326-10-0
- Mol. Weight
- 388.37 Da
- Formula
- C14H24N6O7
PeptideWiki Research Team
Evidence-based research data sourced from PubMed and ClinicalTrials.gov · Last updated: February 25, 2026
Frequently Asked Questions About Pinealon
What is Pinealon?▾
A synthetic tripeptide (Glu-Asp-Arg) from the Khavinson peptide bioregulator series targeting the brain and pineal gland. Reduces neuronal apoptosis, improves cognitive function in aging models, and normalizes circadian rhythm disruption. Distinct from Epithalon despite also targeting the pineal gland.
What are the benefits of Pinealon?▾
Reduces neuronal apoptosis under ischemic/hypoxic conditions
What are the benefits of Pinealon?▾
Improves cognitive function in aging models
What are the side effects of Pinealon?▾
Generally well tolerated
What is the recommended dosage for Pinealon?▾
Typical cycle: 10-day courses 2-3x per year. Often combined with Epithalon. Evening dosing aligns with pineal/circadian effects.
How long should a Pinealon cycle last?▾
10 days per course, 2-3x per year
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