Semax
Also known as: N-Acetyl Semax · MEHFPGP · ACTH 4-10
A synthetic heptapeptide derived from ACTH 4-7 that significantly boosts BDNF levels. Widely used in Russia for cognitive enhancement, stroke recovery, and neurological conditions.
Mechanism of Action
Semax increases BDNF, NGF, and enkephalins in the brain, promoting neuroplasticity and neuroprotection. It modulates dopaminergic and serotonergic systems.
Amino Acid Sequence (7 AAs)
Met-Glu-His-Phe-Pro-Gly-Pro
Benefits
- Significantly increases BDNF levels
- Improves memory, focus, and learning
- Anxiolytic effects
- Neuroprotective
- Studied for ADHD and depression
- Stroke rehabilitation support
- Mood enhancement
Side Effects & Risks
- Mild nasal irritation
- Headaches
- Temporary fatigue
- Irritability with high doses
Where to Buy Semax
4 options across 4 vendors · Sorted cheapest first · All include direct product link
From
$34.99
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Storage & Reconstitution Guide
Storage Temperature
-20°C lyophilized, 4°C reconstituted
24 months (lyophilized), 28 days (reconstituted)
Reconstitution Solvent
Saline (0.9% NaCl) for nasal spray
Swirl gently — do not shake or vortex
Handling Notes
Protect lyophilized peptide from moisture and light. Once reconstituted, keep refrigerated. Discard if solution becomes cloudy or discolored. Use insulin syringe for precise dosing.
Step-by-Step Reconstitution
Gather supplies
BAC water, insulin syringe, alcohol swabs, vial
Disinfect tops
Swab rubber stoppers of both vials with alcohol
Draw BAC water
Pull desired mL of BAC water into syringe
Inject slowly
Inject BAC water down the side of the peptide vial, swirl gently to dissolve
Preclinical Research & Reviews1
Semax regulates expression of BDNF and genes implicated in its signaling
Semax significantly upregulates BDNF and its downstream signaling pathway in rat hippocampus.
Molecular Structure
- CAS Number
- 80714-61-0
- PubChem CID
- 9811102
- Molecular Weight
- 813.9 Da
- Mol. Formula
- C37H51N9O10S
- Amino Acids
- 7-AA peptide
- Wikipedia
- View article
Research Protocol
- Dose Range
- 250–1000 mcg
- Frequency
- Once or twice daily via nasal spray
- Cycle
- 2-4 weeks on, 1-2 weeks off
- Half-Life
- Minutes (active in brain)
- Routes
- intranasal
- Notes
- N-Acetyl Semax Amidate is the most potent form.
Legal & Regulatory Status
Sold for research purposes only. Not for human use. Laws vary by country.
Commonly Stacked With
View all peptide stacks →External Resources
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