Epithalon
Also known as: Epitalon · Epithalone · Ala-Glu-Asp-Gly
A synthetic tetrapeptide that activates telomerase, the enzyme responsible for lengthening telomeres. One of the only compounds with robust evidence for telomere extension in humans.
What is Epithalon? A synthetic tetrapeptide that activates telomerase, the enzyme responsible for lengthening telomeres. One of the only compounds with robust evidence for telomere extension in humans.
How does Epithalon work? Epithalon stimulates the pineal gland to regulate melatonin, activates telomerase to maintain and extend telomere length, and modulates genes involved in aging and longevity.
Benefits of Epithalon: Activates telomerase and extends telomere length; Potential longevity effects; Improves sleep quality via melatonin regulation; Antioxidant properties; Immune function enhancement; Potential anti-cancer effects; Improved mood
Epithalon dosage: Typical cycle: 10-20 days, 1-2x per year.
Research status: Research Only
Source: PeptideWiki — https://www.peptide-wiki.net/peptides/epithalon
Mechanism of Action
Epithalon stimulates the pineal gland to regulate melatonin, activates telomerase to maintain and extend telomere length, and modulates genes involved in aging and longevity.
Amino Acid Sequence (4 AAs)
Ala-Glu-Asp-Gly
Benefits
- Activates telomerase and extends telomere length
- Potential longevity effects
- Improves sleep quality via melatonin regulation
- Antioxidant properties
- Immune function enhancement
- Potential anti-cancer effects
- Improved mood
Side Effects & Risks
- Mild nausea
- Stomach discomfort
- Generally very well tolerated
Where to Buy Epithalon
3 options across 3 vendors · Sorted cheapest first · All include direct product link
From
$34.99
All links are affiliate links — PeptideWiki earns a commission at no extra cost to you. Coupon codes apply at checkout. Prices and availability may change. Always verify COA before purchasing.
Storage & Reconstitution Guide
Storage Temperature
-20°C lyophilized, 4°C reconstituted
24 months (lyophilized), 28 days (reconstituted)
Reconstitution Solvent
Bacteriostatic water (BAC water) or 0.9% saline
Swirl gently — do not shake or vortex
Handling Notes
Protect lyophilized peptide from moisture and light. Once reconstituted, keep refrigerated. Discard if solution becomes cloudy or discolored. Use insulin syringe for precise dosing.
Step-by-Step Reconstitution
Gather supplies
BAC water, insulin syringe, alcohol swabs, vial
Disinfect tops
Swab rubber stoppers of both vials with alcohol
Draw BAC water
Pull desired mL of BAC water into syringe
Inject slowly
Inject BAC water down the side of the peptide vial, swirl gently to dissolve
Preclinical Research & Reviews1
Peptide Epitalon Activates Telomerase in Human Somatic Cells
Epithalon demonstrated activation of telomerase in human somatic cells.
Molecular Structure
- CAS Number
- 307297-39-8
- PubChem CID
- 219042
- Molecular Weight
- 390.35 Da
- Mol. Formula
- C14H22N4O9
- Amino Acids
- 4-AA peptide
- IUPAC Name
- (4S)-4-[[(2S)-2-aminopropanoyl]amino]-5-[[(2S)-3-carboxy-1-(carboxymethylamino)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
- Wikipedia
- View article
Research Protocol
- Dose Range
- 5–10 mg
- Frequency
- Once daily subcutaneous injection
- Cycle
- 10-20 days, 1-2x per year
- Routes
- subcutaneous injectionintramuscular injectionintranasal
- Notes
- Typical cycle: 10-20 days, 1-2x per year.
Legal & Regulatory Status
Sold for research purposes only. Not for human use. Laws vary by country.
Commonly Stacked With
View all peptide stacks →External Resources
PeptideWiki Research Team
Evidence-based research data sourced from PubMed and ClinicalTrials.gov · Last updated: February 25, 2026
Frequently Asked Questions About Epithalon
What is Epithalon?▾
A synthetic tetrapeptide that activates telomerase, the enzyme responsible for lengthening telomeres. One of the only compounds with robust evidence for telomere extension in humans.
What are the benefits of Epithalon?▾
Activates telomerase and extends telomere length
What are the benefits of Epithalon?▾
Potential longevity effects
What are the side effects of Epithalon?▾
Mild nausea
What is the recommended dosage for Epithalon?▾
Typical cycle: 10-20 days, 1-2x per year.
How long should a Epithalon cycle last?▾
10-20 days, 1-2x per year
More Anti-Aging & Longevity Peptides
View all Anti-Aging & Longevity peptides →Livagen
KEDA tetrapeptide
A synthetic tetrapeptide (Lys-Glu-Asp-Ala) from the Khavinson bioregulator series that de-heterochromatinizes age-condensed chromatin in lymphocytes, restoring youthful gene expression patterns. Hepatoprotective and immunomodulatory. One of the most mechanistically unique anti-aging peptides — it directly reactivates genes silenced by chromatin condensation with age.
Thyreogen
Thyroid peptide bioregulator
A thyroid-targeting tetrapeptide bioregulator from the Khavinson series. Normalizes thyroid cell function, thyroid hormone synthesis, and thyroid morphology. Studied for hypothyroidism, autoimmune thyroiditis, and thyroid aging. One of the most widely used Khavinson organ bioregulators given the high prevalence of thyroid dysfunction.
Ventfort
Vascular wall peptide bioregulator
A peptide bioregulator targeting blood vessel walls from the Khavinson series. Normalizes vascular endothelial cell function, reduces oxidative damage to vessel walls, and improves microcirculation. Distinct from Vesugen (which is the synthetic tripeptide form) in being the natural extract-based vascular bioregulator complex.
Vilon
Lys-Glu
A synthetic dipeptide from the Khavinson bioregulator series. Primarily acts as a thymus and immune regulator with demonstrated anti-aging properties.