Livagen
Also known as: KEDA tetrapeptide · Lys-Glu-Asp-Ala · Liver peptide bioregulator
A synthetic tetrapeptide (Lys-Glu-Asp-Ala) from the Khavinson bioregulator series that de-heterochromatinizes age-condensed chromatin in lymphocytes, restoring youthful gene expression patterns. Hepatoprotective and immunomodulatory. One of the most mechanistically unique anti-aging peptides — it directly reactivates genes silenced by chromatin condensation with age.
Mechanism of Action
Livagen penetrates cell nuclei and binds to condensed chromatin regions (heterochromatin) that have been silenced with aging, particularly histone H1-DNA interactions. This de-condensation reactivates ribosomal genes and other age-silenced transcriptional programs. In human lymphocyte cultures, Livagen restores ribosomal RNA synthesis rates to youthful levels within 24 hours. Also has hepatoprotective effects via anti-apoptotic signaling in liver cells.
Benefits
- Unique mechanism: directly de-condenses age-silenced chromatin
- Reactivates ribosomal genes and silenced transcription
- Restores youthful gene expression in lymphocytes
- Hepatoprotective and anti-apoptotic in liver
- Immunomodulatory via lymphocyte activation
- Anti-aging at the fundamental epigenetic level
- Synergistic with other anti-aging peptide bioregulators
Side Effects & Risks
- Limited standalone clinical data beyond Russian research
- Well tolerated in available studies
- Injection site reactions
Storage & Reconstitution Guide
Storage Temperature
-20°C (lyophilized)
24 months (lyophilized), 28 days (reconstituted)
Reconstitution Solvent
Bacteriostatic water (BAC water)
Swirl gently — do not shake or vortex
Handling Notes
Protect lyophilized peptide from moisture and light. Once reconstituted, keep refrigerated. Discard if solution becomes cloudy or discolored. Use insulin syringe for precise dosing.
Step-by-Step Reconstitution
Gather supplies
BAC water, insulin syringe, alcohol swabs, vial
Disinfect tops
Swab rubber stoppers of both vials with alcohol
Draw BAC water
Pull desired mL of BAC water into syringe
Inject slowly
Inject BAC water down the side of the peptide vial, swirl gently to dissolve
Research Protocol
- Dose Range
- 1–2 mg
- Frequency
- Daily injection for 10-day courses
- Cycle
- 10-day courses, 1-2x per year
- Routes
- subcutaneous injection
- Notes
- Standard Khavinson protocol: 1-2mg/day subcutaneous or IM for 10 days, 1-2x per year.
Legal & Regulatory Status
Sold for research purposes only. Not for human use. Laws vary by country.
Commonly Stacked With
View all peptide stacks →External Resources
Chemical Properties
- CAS Number
- 137562-23-3
- Mol. Weight
- 447.49 Da
- Formula
- C18H33N5O7
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