Dihexa
Also known as: PNB-0408 · N-hexanoic-Tyr-Ile-(6) aminohexanoic amide
An angiotensin IV-derived peptide that is reportedly millions of times more potent than BDNF at forming functional synaptic connections. Promotes dendritic spine growth via the HGF/c-Met signaling pathway. Researched for Alzheimer's disease, cognitive enhancement, and neuroplasticity.
What is Dihexa? An angiotensin IV-derived peptide that is reportedly millions of times more potent than BDNF at forming functional synaptic connections. Promotes dendritic spine growth via the HGF/c-Met signaling pathway. Researched for Alzheimer's disease, cognitive enhancement, and neuroplasticity.
How does Dihexa work? Dihexa potentiates HGF (Hepatocyte Growth Factor) signaling through its c-Met receptor, which promotes dendritic spine formation and synaptic connectivity. Unlike BDNF which cannot cross the blood-brain barrier, Dihexa is orally bioavailable and crosses the BBB readily. It reverses cognitive deficits in models of Alzheimer's disease and aging.
Benefits of Dihexa: Dramatically increases synaptic connectivity (dendritic spine formation); Orally bioavailable and crosses the blood-brain barrier; Reverses cognitive deficits in Alzheimer's models; Improves memory, learning, and cognitive performance; Acts via HGF/c-Met pathway — distinct from other nootropics; Long-lasting effects even after cessation
Dihexa dosage: Highly potent — start with 5mg. Effects may persist for weeks after stopping. Do not combine with other pro-cognitive compounds carelessly.
Dihexa half-life: Long (effects persist days)
Research status: Research Only
Source: PeptideWiki — https://www.peptide-wiki.net/peptides/dihexa
Mechanism of Action
Dihexa potentiates HGF (Hepatocyte Growth Factor) signaling through its c-Met receptor, which promotes dendritic spine formation and synaptic connectivity. Unlike BDNF which cannot cross the blood-brain barrier, Dihexa is orally bioavailable and crosses the BBB readily. It reverses cognitive deficits in models of Alzheimer's disease and aging.
Benefits
- Dramatically increases synaptic connectivity (dendritic spine formation)
- Orally bioavailable and crosses the blood-brain barrier
- Reverses cognitive deficits in Alzheimer's models
- Improves memory, learning, and cognitive performance
- Acts via HGF/c-Met pathway — distinct from other nootropics
- Long-lasting effects even after cessation
Side Effects & Risks
- Potentially powerful psychostimulant effects
- May be too stimulating for some users
- Long-lasting neurological changes — effects persist after stopping
- Limited human clinical data
- Anxiety or overstimulation at high doses
Storage & Reconstitution Guide
Storage Temperature
-20°C (lyophilized)
24 months (lyophilized), 28 days (reconstituted)
Reconstitution Solvent
Bacteriostatic water (BAC water)
Swirl gently — do not shake or vortex
Handling Notes
Protect lyophilized peptide from moisture and light. Once reconstituted, keep refrigerated. Discard if solution becomes cloudy or discolored. Use insulin syringe for precise dosing.
Step-by-Step Reconstitution
Gather supplies
BAC water, insulin syringe, alcohol swabs, vial
Disinfect tops
Swab rubber stoppers of both vials with alcohol
Draw BAC water
Pull desired mL of BAC water into syringe
Inject slowly
Inject BAC water down the side of the peptide vial, swirl gently to dissolve
Preclinical Research & Reviews1
Dihexa potentiates HGF/c-Met-induced neural repair
Dihexa potentiated HGF/c-Met signaling 1,000,000-fold compared to BDNF, reversing cognitive deficits in Alzheimer models.
Research Protocol
- Dose Range
- 5–10 mg
- Frequency
- Once daily oral or sublingual
- Cycle
- 2-4 weeks on, then assess
- Half-Life
- Long (effects persist days)
- Routes
- oralsublingual
- Notes
- Highly potent — start with 5mg. Effects may persist for weeks after stopping. Do not combine with other pro-cognitive compounds carelessly.
Legal & Regulatory Status
Sold for research purposes only. Not for human use. Laws vary by country.
Commonly Stacked With
View all peptide stacks →External Resources
PeptideWiki Research Team
Evidence-based research data sourced from PubMed and ClinicalTrials.gov · Last updated: February 25, 2026
Frequently Asked Questions About Dihexa
What is Dihexa?▾
An angiotensin IV-derived peptide that is reportedly millions of times more potent than BDNF at forming functional synaptic connections. Promotes dendritic spine growth via the HGF/c-Met signaling pathway. Researched for Alzheimer's disease, cognitive enhancement, and neuroplasticity.
What are the benefits of Dihexa?▾
Dramatically increases synaptic connectivity (dendritic spine formation)
What are the benefits of Dihexa?▾
Orally bioavailable and crosses the blood-brain barrier
What are the side effects of Dihexa?▾
Potentially powerful psychostimulant effects
What is the recommended dosage for Dihexa?▾
Highly potent — start with 5mg. Effects may persist for weeks after stopping. Do not combine with other pro-cognitive compounds carelessly.
How long should a Dihexa cycle last?▾
2-4 weeks on, then assess
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