SLU-PP-332
Also known as: SLU PP 332 · ERR agonist · Exercise-in-a-pill
A pan-agonist of all three estrogen-related receptors (ERRα, ERRβ, ERRγ) that activates the same genetic programs triggered by endurance exercise. Mice given SLU-PP-332 showed 70% greater endurance capacity and significant fat loss without exercise.
Mechanism of Action
SLU-PP-332 activates ERRα, ERRβ, and ERRγ simultaneously — nuclear receptors that regulate oxidative metabolism in muscle, fat, heart, and brain. ERR activation mimics exercise-induced adaptations: increased mitochondrial biogenesis, fat oxidation, and fast-to-slow muscle fiber conversion. This is distinct from AMPK activation (AICAR) but synergistic with it.
Benefits
- Activates endurance exercise gene programs without exercise
- 70% greater running endurance in mouse models
- Significant fat loss and metabolic improvements
- Increases mitochondrial biogenesis in muscle
- Heart failure research (improves cardiac muscle function)
- Kidney disease research (energizes failing kidney cells)
- Metabolic disease treatment potential
Side Effects & Risks
- Very limited human data (research compound as of 2025)
- Unknown long-term effects
- Potential overactivation of estrogen-related pathways
- May affect reproductive hormone pathways
Where to Buy SLU-PP-332
2 options across 2 vendors · Sorted cheapest first · All include direct product link
From
$68.00
All links are affiliate links — PeptideWiki earns a commission at no extra cost to you. Coupon codes apply at checkout. Prices and availability may change. Always verify COA before purchasing.
Storage & Reconstitution Guide
Storage Temperature
Room temperature, protect from moisture
24 months (lyophilized), 28 days (reconstituted)
Reconstitution Solvent
Oral capsule — no reconstitution needed
Swirl gently — do not shake or vortex
Handling Notes
Protect lyophilized peptide from moisture and light. Once reconstituted, keep refrigerated. Discard if solution becomes cloudy or discolored. Use insulin syringe for precise dosing.
Step-by-Step Reconstitution
Gather supplies
BAC water, insulin syringe, alcohol swabs, vial
Disinfect tops
Swab rubber stoppers of both vials with alcohol
Draw BAC water
Pull desired mL of BAC water into syringe
Inject slowly
Inject BAC water down the side of the peptide vial, swirl gently to dissolve
Preclinical Research & Reviews1
SLU-PP-332 activates exercise-regulated ERRs to increase endurance
Pan-ERR agonist SLU-PP-332 increased running endurance 70% and activated the same gene programs as endurance exercise in mice.
Research Protocol
- Dose Range
- 1000 mcg
- Frequency
- Once daily oral
- Cycle
- 4-8 weeks
- Routes
- oral
- Notes
- Current research uses 1mg/day oral. Very limited human data. Monitor hormones with extended use.
Legal & Regulatory Status
Sold for research purposes only. Not for human use. Laws vary by country.
Commonly Stacked With
View all peptide stacks →External Resources
More in Weight Management
5-Amino-1-methylquinolinium
A small molecule inhibitor of NNMT enzyme that boosts metabolism and promotes fat cell apoptosis. Shows promise as a novel anti-obesity agent in preclinical research.
LY3437943
An emerging triple agonist targeting GLP-1, GIP, and glucagon receptors simultaneously. Phase 3 clinical trials show unprecedented weight loss of up to 24% body weight.
AOD9604
A synthetic fragment of the C-terminus of HGH (amino acids 176-191) that retains the fat-burning properties of growth hormone without affecting blood sugar or IGF-1 levels.
Mitochondrial Open Reading Frame of the 12S rRNA-c
A mitochondria-derived peptide that acts as a metabolic regulator, improving insulin sensitivity, exercise capacity, and potentially mimicking caloric restriction.