Tesamorelin
Also known as: Egrifta · TH9507
An FDA-approved synthetic GHRH analog originally developed to treat HIV-associated lipodystrophy. Highly effective at reducing visceral adipose tissue.
Mechanism of Action
Tesamorelin is a 44-amino acid synthetic GHRH analog that stabilizes GHRH against enzymatic degradation. It binds GHRH receptors on the pituitary, increasing GH and subsequently IGF-1. Its primary clinical action is lipolysis of visceral adipose tissue, with studies showing average 17% reductions in visceral fat.
Amino Acid Sequence (44 AAs)
Trans-3-hexenoic acid-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH₂
Benefits
- Significant reduction in visceral fat (average 17% in clinical trials)
- Improved metabolic markers (triglycerides, HDL)
- Increased IGF-1 and GH levels
- Potential cognitive benefits
- FDA-approved for HIV lipodystrophy
- Improved body composition
Side Effects & Risks
- Injection site reactions
- Peripheral edema
- Arthralgia
- Myalgia
- Potential glucose intolerance
- Carpal tunnel symptoms
Where to Buy Tesamorelin
1 option across 1 vendor · Sorted cheapest first · All include direct product link
From
$49.99
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Storage & Reconstitution Guide
Storage Temperature
-20°C lyophilized, 4°C reconstituted
24 months (lyophilized), 28 days (reconstituted)
Reconstitution Solvent
Bacteriostatic water (BAC water)
Swirl gently — do not shake or vortex
Handling Notes
Protect lyophilized peptide from moisture and light. Once reconstituted, keep refrigerated. Discard if solution becomes cloudy or discolored. Use insulin syringe for precise dosing.
Step-by-Step Reconstitution
Gather supplies
BAC water, insulin syringe, alcohol swabs, vial
Disinfect tops
Swab rubber stoppers of both vials with alcohol
Draw BAC water
Pull desired mL of BAC water into syringe
Inject slowly
Inject BAC water down the side of the peptide vial, swirl gently to dissolve
Clinical Trials & Human Studies1 trial
Phase 3 RCT of Tesamorelin for HIV-Associated Lipodystrophy
In 816 HIV-positive patients with abdominal lipodystrophy, tesamorelin 2mg/day for 26 weeks reduced visceral adipose tissue by 13.1% vs placebo (-0.5%, p<0.001). Waist circumference decreased 2.4 cm vs 0.3 cm (p<0.001).
Primary Outcome
Visceral adipose tissue area (VAT) change
p-value
<0.001
Igf1 Change
+138 ng/mL vs -9.1 ng/mL
Placebo Vat Change
-0.5%
Waist Circumference
-2.4 cm (tesamorelin) vs -0.3 cm (placebo)
Tesamorelin Vat Change
-13.1%
Molecular Structure
- CAS Number
- 218949-48-5
- PubChem CID
- 16137828
- Molecular Weight
- 5,136 Da
- Mol. Formula
- C221H366N72O67S
- Amino Acids
- 44-AA peptide
- Wikipedia
- View article
Research Protocol
- Dose Range
- 1–2 mg
- Frequency
- Once daily subcutaneous injection
- Cycle
- 4-12 weeks
- Half-Life
- 26 minutes
- Routes
- subcutaneous injection
- Notes
- Clinical dose is 2mg/day.
Legal & Regulatory Status
Sold for research purposes only. Not for human use. Laws vary by country.
Commonly Stacked With
View all peptide stacks →External Resources
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