MGF (Mechano Growth Factor)
Also known as: Mechano Growth Factor · IGF-1Ec · PEG-MGF
A splice variant of IGF-1 released in muscle fibers in response to mechanical damage. Activates muscle satellite cells to initiate repair and hypertrophy.
What is MGF (Mechano Growth Factor)? A splice variant of IGF-1 released in muscle fibers in response to mechanical damage. Activates muscle satellite cells to initiate repair and hypertrophy.
How does MGF (Mechano Growth Factor) work? MGF is generated by alternative splicing of the IGF-1 gene. It activates muscle stem cells (satellite cells) to proliferate and fuse with existing muscle fibers, initiating the hypertrophic response.
Benefits of MGF (Mechano Growth Factor): Activates muscle satellite cells for repair and growth; Maximizes post-workout hypertrophy; Rapid local tissue repair; Supports muscle maintenance during caloric restriction; Synergistic with IGF-1 LR3
MGF (Mechano Growth Factor) dosage: Best used immediately post-workout.
MGF (Mechano Growth Factor) half-life: Minutes (MGF)
Research status: Research Only
Source: PeptideWiki — https://www.peptide-wiki.net/peptides/mgf
Mechanism of Action
MGF is generated by alternative splicing of the IGF-1 gene. It activates muscle stem cells (satellite cells) to proliferate and fuse with existing muscle fibers, initiating the hypertrophic response.
Benefits
- Activates muscle satellite cells for repair and growth
- Maximizes post-workout hypertrophy
- Rapid local tissue repair
- Supports muscle maintenance during caloric restriction
- Synergistic with IGF-1 LR3
Side Effects & Risks
- Hypoglycemia risk
- Local muscle swelling at injection site
- Joint discomfort
Where to Buy MGF (Mechano Growth Factor)
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Storage & Reconstitution Guide
Storage Temperature
-20°C lyophilized, 4°C reconstituted
24 months (lyophilized), 28 days (reconstituted)
Reconstitution Solvent
Bacteriostatic water (BAC water)
Swirl gently — do not shake or vortex
Handling Notes
Protect lyophilized peptide from moisture and light. Once reconstituted, keep refrigerated. Discard if solution becomes cloudy or discolored. Use insulin syringe for precise dosing.
Step-by-Step Reconstitution
Gather supplies
BAC water, insulin syringe, alcohol swabs, vial
Disinfect tops
Swab rubber stoppers of both vials with alcohol
Draw BAC water
Pull desired mL of BAC water into syringe
Inject slowly
Inject BAC water down the side of the peptide vial, swirl gently to dissolve
Research Protocol
- Dose Range
- 100–200 mcg
- Frequency
- Post-workout, localized injection
- Cycle
- 4-6 weeks
- Half-Life
- Minutes (MGF)
- Routes
- intramuscular injection
- Notes
- Best used immediately post-workout.
Legal & Regulatory Status
Sold for research purposes only. Not for human use. Laws vary by country.
Commonly Stacked With
View all peptide stacks →External Resources
PeptideWiki Research Team
Evidence-based research data sourced from PubMed and ClinicalTrials.gov · Last updated: February 25, 2026
Frequently Asked Questions About MGF (Mechano Growth Factor)
What is MGF (Mechano Growth Factor)?▾
A splice variant of IGF-1 released in muscle fibers in response to mechanical damage. Activates muscle satellite cells to initiate repair and hypertrophy.
What are the benefits of MGF (Mechano Growth Factor)?▾
Activates muscle satellite cells for repair and growth
What are the benefits of MGF (Mechano Growth Factor)?▾
Maximizes post-workout hypertrophy
What are the side effects of MGF (Mechano Growth Factor)?▾
Hypoglycemia risk
What is the recommended dosage for MGF (Mechano Growth Factor)?▾
Best used immediately post-workout.
How long should a MGF (Mechano Growth Factor) cycle last?▾
4-6 weeks
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