IGF-1 LR3
Also known as: IGF-1 · Insulin-Like Growth Factor 1 · Long R3 IGF-1
A long-acting analog of IGF-1 with a modified arginine substitution that extends its half-life. Directly stimulates muscle protein synthesis independent of GH.
Mechanism of Action
IGF-1 LR3 is an 83-amino acid analog of endogenous IGF-1 that reduces its affinity for IGF-binding proteins, dramatically extending its half-life. It directly binds IGF-1 receptors in muscle and other tissues to stimulate protein synthesis.
Benefits
- Direct muscle protein synthesis stimulation
- Significant lean muscle mass increases
- Enhanced fat oxidation
- Improved nitrogen retention
- Accelerated recovery from training
- Anti-catabolic effects during caloric restriction
Side Effects & Risks
- Hypoglycemia (most serious risk)
- Stomach discomfort
- Joint swelling
- Jaw pain
- Potential organ growth with excessive dosing
- Water retention
Where to Buy IGF-1 LR3
2 options across 2 vendors · Sorted cheapest first · All include direct product link
From
$68.00
All links are affiliate links — PeptideWiki earns a commission at no extra cost to you. Coupon codes apply at checkout. Prices and availability may change. Always verify COA before purchasing.
Storage & Reconstitution Guide
Storage Temperature
-80°C long-term, -20°C up to 6 months lyophilized
24 months (lyophilized), 28 days (reconstituted)
Reconstitution Solvent
Bacteriostatic water (BAC water); always use with carbohydrates
Swirl gently — do not shake or vortex
Handling Notes
Protect lyophilized peptide from moisture and light. Once reconstituted, keep refrigerated. Discard if solution becomes cloudy or discolored. Use insulin syringe for precise dosing.
Step-by-Step Reconstitution
Gather supplies
BAC water, insulin syringe, alcohol swabs, vial
Disinfect tops
Swab rubber stoppers of both vials with alcohol
Draw BAC water
Pull desired mL of BAC water into syringe
Inject slowly
Inject BAC water down the side of the peptide vial, swirl gently to dissolve
Research Protocol
- Dose Range
- 20–100 mcg
- Frequency
- Once daily post-workout
- Cycle
- 2-4 weeks
- Half-Life
- 20-30 hours
- Routes
- subcutaneous injectionintramuscular injection
- Notes
- Always administer with carbohydrates to prevent hypoglycemia.
Legal & Regulatory Status
Sold for research purposes only. Not for human use. Laws vary by country.
Commonly Stacked With
View all peptide stacks →External Resources
Chemical Properties
- CAS Number
- 946870-92-4
- Mol. Weight
- 9,117 Da
- Formula
- C400H625N111O115S9
More in Body Composition
Ibutamoren
A non-peptide, orally active growth hormone secretagogue that mimics ghrelin, significantly elevating GH and IGF-1 levels. Unique in being orally bioavailable.
Modified GRF 1-29
A synthetic 29-amino acid GHRH analog with 4 amino acid substitutions that improve stability and receptor affinity compared to Sermorelin. Unlike CJC-1295 DAC, it has no Drug Affinity Complex, giving it a short 30-minute half-life that mimics the body's natural pulsatile GHRH secretion when co-administered with a GHRP.
FST-344
A naturally occurring protein that inhibits myostatin and activin, effectively removing the biological ceiling on muscle growth.
Mechano Growth Factor
A splice variant of IGF-1 released in muscle fibers in response to mechanical damage. Activates muscle satellite cells to initiate repair and hypertrophy.