CJC-1295
Also known as: CJC-1295 DAC Ā· Modified GRF 1-29 Ā· Mod GRF 1-29 Ā· CJC1295
A synthetic analog of growth hormone-releasing hormone (GHRH) that extends the half-life of endogenous GHRH. One of the most popular peptides for muscle growth and fat loss when stacked with a GHRP like Ipamorelin.
What is CJC-1295? A synthetic analog of growth hormone-releasing hormone (GHRH) that extends the half-life of endogenous GHRH. One of the most popular peptides for muscle growth and fat loss when stacked with a GHRP like Ipamorelin.
How does CJC-1295 work? CJC-1295 is a 30-amino acid GHRH analog modified with a Drug Affinity Complex (DAC) to extend its half-life from minutes to days. It binds to GHRH receptors on the pituitary gland, stimulating pulsatile GH secretion and subsequently increasing IGF-1.
Benefits of CJC-1295: Sustained elevation of GH and IGF-1 levels; Increased lean muscle mass; Enhanced fat metabolism and lipolysis; Improved recovery from training and injury; Better sleep quality and REM sleep; Improved skin elasticity and collagen synthesis; Potential anti-aging effects
CJC-1295 dosage: Non-DAC version dosed at 100-200mcg per injection, 1-3x daily.
CJC-1295 half-life: 6-8 days (DAC)
Research status: Research Only
Source: PeptideWiki ā https://www.peptide-wiki.net/peptides/cjc-1295
Mechanism of Action
CJC-1295 is a 30-amino acid GHRH analog modified with a Drug Affinity Complex (DAC) to extend its half-life from minutes to days. It binds to GHRH receptors on the pituitary gland, stimulating pulsatile GH secretion and subsequently increasing IGF-1.
Amino Acid Sequence (30 AAs)
Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NHā
Benefits
- Sustained elevation of GH and IGF-1 levels
- Increased lean muscle mass
- Enhanced fat metabolism and lipolysis
- Improved recovery from training and injury
- Better sleep quality and REM sleep
- Improved skin elasticity and collagen synthesis
- Potential anti-aging effects
Side Effects & Risks
- Water retention
- Mild fatigue
- Headaches
- Flushing
- Joint pain at high doses
- Potential insulin resistance with prolonged use
Where to Buy CJC-1295
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From
$24.00
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Storage & Reconstitution Guide
Storage Temperature
-20Ā°C lyophilized, 4Ā°C reconstituted
24 months (lyophilized), 28 days (reconstituted)
Reconstitution Solvent
Bacteriostatic water (BAC water)
Swirl gently ā do not shake or vortex
Handling Notes
Protect lyophilized peptide from moisture and light. Once reconstituted, keep refrigerated. Discard if solution becomes cloudy or discolored. Use insulin syringe for precise dosing.
Step-by-Step Reconstitution
Gather supplies
BAC water, insulin syringe, alcohol swabs, vial
Disinfect tops
Swab rubber stoppers of both vials with alcohol
Draw BAC water
Pull desired mL of BAC water into syringe
Inject slowly
Inject BAC water down the side of the peptide vial, swirl gently to dissolve
Preclinical Research & Reviews1
CJC-1295 Phase 1: Dose-Dependent GH and IGF-1 Elevations
Phase 1 dose-escalation in ~65 healthy adults. Single SC dose of CJC-1295 (30-120 Āµg/kg) produced dose-dependent, sustained GH increases lasting >6 days. IGF-1 increased 28-44% from baseline at 30-60 Āµg/kg. GH area-under-the-curve increased 2-10x vs placebo.
Primary Outcome
GH and IGF-1 levels post-dose
Gh Auc
2-10x increase vs placebo
Gh Duration
Elevated >6 days post single dose
Igf1 Increase
28-44% from baseline (30-60 Āµg/kg)
Adverse Events
Injection site reactions, water retention; no serious events
Molecular Structure
- CAS Number
- 863288-34-0
- PubChem CID
- 91976842
- Molecular Weight
- 3,647.25 Da
- Mol. Formula
- C152H252N44O42
- Amino Acids
- 30-AA peptide
- Wikipedia
- View article
Research Protocol
- Dose Range
- 1000ā2000 mcg
- Frequency
- Once or twice weekly (DAC version)
- Cycle
- 8-12 weeks
- Half-Life
- 6-8 days (DAC)
- Routes
- subcutaneous injection
- Notes
- Non-DAC version dosed at 100-200mcg per injection, 1-3x daily.
Legal & Regulatory Status
Sold for research purposes only. Not for human use. Laws vary by country.
Commonly Stacked With
View all peptide stacks āExternal Resources
PeptideWiki Research Team
Evidence-based research data sourced from PubMed and ClinicalTrials.gov Ā· Last updated: February 25, 2026
Frequently Asked Questions About CJC-1295
What is CJC-1295?ā¾
A synthetic analog of growth hormone-releasing hormone (GHRH) that extends the half-life of endogenous GHRH. One of the most popular peptides for muscle growth and fat loss when stacked with a GHRP like Ipamorelin.
What are the benefits of CJC-1295?ā¾
Sustained elevation of GH and IGF-1 levels
What are the benefits of CJC-1295?ā¾
Increased lean muscle mass
What are the side effects of CJC-1295?ā¾
Water retention
What is the recommended dosage for CJC-1295?ā¾
Non-DAC version dosed at 100-200mcg per injection, 1-3x daily.
How long should a CJC-1295 cycle last?ā¾
8-12 weeks
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