CJC-1295 No DAC (Mod GRF 1-29)
Also known as: Modified GRF 1-29 · CJC-1295 no DAC · Mod GRF · Sermorelin-like · GRF(1-29)
A synthetic 29-amino acid GHRH analog with 4 amino acid substitutions that improve stability and receptor affinity compared to Sermorelin. Unlike CJC-1295 DAC, it has no Drug Affinity Complex, giving it a short 30-minute half-life that mimics the body's natural pulsatile GHRH secretion when co-administered with a GHRP.
What is CJC-1295 No DAC (Mod GRF 1-29)? A synthetic 29-amino acid GHRH analog with 4 amino acid substitutions that improve stability and receptor affinity compared to Sermorelin. Unlike CJC-1295 DAC, it has no Drug Affinity Complex, giving it a short 30-minute half-life that mimics the body's natural pulsatile GHRH secretion when co-administered with a GHRP.
How does CJC-1295 No DAC (Mod GRF 1-29) work? Mod GRF 1-29 binds to GHRH receptors on pituitary somatotrophs and stimulates GH release in synchrony with an administered GHRP. Because of its short half-life, it produces a sharp, physiological GH pulse rather than the sustained elevation from CJC-1295 DAC. The 4 amino acid substitutions make it more stable than Sermorelin.
Benefits of CJC-1295 No DAC (Mod GRF 1-29): Produces physiological pulsatile GH release; More stable than Sermorelin; Synergistic with any GHRP for 3-5x GH amplification; Flexible dosing schedule; Lower desensitization risk vs. DAC version; More affordable than DAC version
CJC-1295 No DAC (Mod GRF 1-29) dosage: MUST be co-administered with a GHRP (Ipamorelin, GHRP-6, etc.) within 30 seconds for synergistic effect. Dose: 100-200mcg per injection.
CJC-1295 No DAC (Mod GRF 1-29) half-life: 30 minutes
Research status: Research Only
Source: PeptideWiki — https://www.peptide-wiki.net/peptides/mod-grf-1-29
Mechanism of Action
Mod GRF 1-29 binds to GHRH receptors on pituitary somatotrophs and stimulates GH release in synchrony with an administered GHRP. Because of its short half-life, it produces a sharp, physiological GH pulse rather than the sustained elevation from CJC-1295 DAC. The 4 amino acid substitutions make it more stable than Sermorelin.
Benefits
- Produces physiological pulsatile GH release
- More stable than Sermorelin
- Synergistic with any GHRP for 3-5x GH amplification
- Flexible dosing schedule
- Lower desensitization risk vs. DAC version
- More affordable than DAC version
Side Effects & Risks
- Very short half-life requires co-administration with GHRP
- Must be dosed 1-3x daily (more injections)
- Water retention
- Mild headache
Where to Buy CJC-1295 No DAC (Mod GRF 1-29)
1 option across 1 vendor · Sorted cheapest first · All include direct product link
From
$39.95
All links are affiliate links — PeptideWiki earns a commission at no extra cost to you. Coupon codes apply at checkout. Prices and availability may change. Always verify COA before purchasing.
Storage & Reconstitution Guide
Storage Temperature
-20°C (lyophilized)
24 months (lyophilized), 28 days (reconstituted)
Reconstitution Solvent
Bacteriostatic water (BAC water)
Swirl gently — do not shake or vortex
Handling Notes
Protect lyophilized peptide from moisture and light. Once reconstituted, keep refrigerated. Discard if solution becomes cloudy or discolored. Use insulin syringe for precise dosing.
Step-by-Step Reconstitution
Gather supplies
BAC water, insulin syringe, alcohol swabs, vial
Disinfect tops
Swab rubber stoppers of both vials with alcohol
Draw BAC water
Pull desired mL of BAC water into syringe
Inject slowly
Inject BAC water down the side of the peptide vial, swirl gently to dissolve
Molecular Structure
- CAS Number
- 863288-34-0
- PubChem CID
- 863288
- Molecular Weight
- 3,367 Da
- Mol. Formula
- C152H252N44O42
- Amino Acids
- 29-AA peptide
Research Protocol
- Dose Range
- 100–200 mcg
- Frequency
- 1-3x daily, always with a GHRP
- Cycle
- 8-16 weeks
- Half-Life
- 30 minutes
- Routes
- subcutaneous injection
- Notes
- MUST be co-administered with a GHRP (Ipamorelin, GHRP-6, etc.) within 30 seconds for synergistic effect. Dose: 100-200mcg per injection.
Legal & Regulatory Status
Sold for research purposes only. Not for human use. Laws vary by country.
Commonly Stacked With
View all peptide stacks →External Resources
PeptideWiki Research Team
Evidence-based research data sourced from PubMed and ClinicalTrials.gov · Last updated: February 25, 2026
Frequently Asked Questions About CJC-1295 No DAC (Mod GRF 1-29)
What is CJC-1295 No DAC (Mod GRF 1-29)?▾
A synthetic 29-amino acid GHRH analog with 4 amino acid substitutions that improve stability and receptor affinity compared to Sermorelin. Unlike CJC-1295 DAC, it has no Drug Affinity Complex, giving it a short 30-minute half-life that mimics the body's natural pulsatile GHRH secretion when co-administered with a GHRP.
What are the benefits of CJC-1295 No DAC (Mod GRF 1-29)?▾
Produces physiological pulsatile GH release
What are the benefits of CJC-1295 No DAC (Mod GRF 1-29)?▾
More stable than Sermorelin
What are the side effects of CJC-1295 No DAC (Mod GRF 1-29)?▾
Very short half-life requires co-administration with GHRP
What is the recommended dosage for CJC-1295 No DAC (Mod GRF 1-29)?▾
MUST be co-administered with a GHRP (Ipamorelin, GHRP-6, etc.) within 30 seconds for synergistic effect. Dose: 100-200mcg per injection.
How long should a CJC-1295 No DAC (Mod GRF 1-29) cycle last?▾
8-16 weeks
More Body Composition Peptides
View all Body Composition peptides →MK-677 (Ibutamoren)
Ibutamoren
A non-peptide, orally active growth hormone secretagogue that mimics ghrelin, significantly elevating GH and IGF-1 levels. Unique in being orally bioavailable.
Follistatin-344
FST-344
A naturally occurring protein that inhibits myostatin and activin, effectively removing the biological ceiling on muscle growth.
MGF (Mechano Growth Factor)
Mechano Growth Factor
A splice variant of IGF-1 released in muscle fibers in response to mechanical damage. Activates muscle satellite cells to initiate repair and hypertrophy.
Hexarelin
Examorelin
A synthetic hexapeptide GHRP with the highest GH-releasing potency among the GHRP family. Notable for both its muscle-building effects and documented cardiovascular benefits.