Ipamorelin
Also known as: Ipamorelin acetate · NNC 26-0161
A selective growth hormone secretagogue and ghrelin mimetic that stimulates GH release without significantly elevating cortisol or prolactin. One of the cleanest and most widely used peptides for body recomposition.
Mechanism of Action
Ipamorelin is a pentapeptide that selectively binds to the growth hormone secretagogue receptor (GHS-R), stimulating the pituitary gland to release growth hormone in a pulsatile, physiological manner. Unlike other GHRPs, it does not significantly elevate cortisol, prolactin, or ACTH, making it one of the most selective GH-releasing peptides available.
Amino Acid Sequence (5 AAs)
Aib-His-D-2Nal-D-Phe-Lys-NH₂
Benefits
- Increases growth hormone and IGF-1 levels
- Promotes lean muscle mass development
- Supports fat loss and body recomposition
- Improves sleep quality and recovery
- Enhances bone density over time
- Minimal cortisol or prolactin elevation compared to other GHRPs
Side Effects & Risks
- Mild headaches (often from GH surge)
- Water retention, especially early in use
- Mild fatigue or lethargy
- Potential numbness or tingling in extremities
- Flushing at injection site
Where to Buy Ipamorelin
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Storage & Reconstitution Guide
Storage Temperature
-20°C lyophilized, 4°C reconstituted
24 months (lyophilized), 28 days (reconstituted)
Reconstitution Solvent
Bacteriostatic water (BAC water)
Swirl gently — do not shake or vortex
Handling Notes
Protect lyophilized peptide from moisture and light. Once reconstituted, keep refrigerated. Discard if solution becomes cloudy or discolored. Use insulin syringe for precise dosing.
Step-by-Step Reconstitution
Gather supplies
BAC water, insulin syringe, alcohol swabs, vial
Disinfect tops
Swab rubber stoppers of both vials with alcohol
Draw BAC water
Pull desired mL of BAC water into syringe
Inject slowly
Inject BAC water down the side of the peptide vial, swirl gently to dissolve
Clinical Trials & Human Studies1 trial
Ipamorelin for Post-Operative Ileus: Phase II RCT
Phase 2 RCT in 117 patients post-abdominal surgery. Ipamorelin 200µg IV TID: first tolerated meal at 25.3h vs 32.6h placebo (p=0.15; not statistically significant). Time to first bowel sound: 15.6h vs 20.3h (p=0.04). Well-tolerated with no significant adverse events.
Primary Outcome
Time to first tolerated meal
p-value
0.15 (not significant)
Placebo Time
32.6 hours
Ipamorelin Time
25.3 hours
Bowel Sound Time
15.6h vs 20.3h (p=0.04)
Primary endpoint not met; secondary bowel endpoint met
Preclinical Research & Reviews1
Ipamorelin, the first selective growth hormone secretagogue
Ipamorelin selectively releases GH without significant effects on ACTH, cortisol, or prolactin.
Molecular Structure
- CAS Number
- 170851-70-4
- PubChem CID
- 9831659
- Molecular Weight
- 711.9 Da
- Mol. Formula
- C38H49N9O5
- Amino Acids
- 5-AA peptide
- Wikipedia
- View article
Research Protocol
- Dose Range
- 200–300 mcg
- Frequency
- 1-3x daily, ideally before bed or post-workout
- Cycle
- 8-12 weeks
- Half-Life
- 2 hours
- Routes
- subcutaneous injection
- Notes
- Commonly stacked with CJC-1295. 8-12 week cycles recommended.
Legal & Regulatory Status
Sold for research purposes only. Not for human use. Laws vary by country.
Commonly Stacked With
View all peptide stacks →External Resources
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