Sermorelin
Also known as: GRF 1-29 NH2 · GHRH 1-29 · Geref
A 29-amino acid synthetic analog of endogenous GHRH that stimulates natural GH production. Clinically used for GH deficiency and widely used in anti-aging medicine as a safer alternative to exogenous HGH.
Mechanism of Action
Sermorelin consists of the first 29 amino acids of GHRH and directly stimulates the anterior pituitary to secrete endogenous growth hormone. It works via a feedback mechanism that prevents GH levels from rising too high, making it safer than direct HGH administration.
Amino Acid Sequence (29 AAs)
Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH₂
Benefits
- Restores natural GH secretion patterns
- Supports lean muscle growth and maintenance
- Promotes fat reduction, especially visceral fat
- Improves sleep quality and circadian rhythm
- Enhances immune function
- Thicker hair and stronger nails
- Improved wound healing
- Cardiovascular health support
Side Effects & Risks
- Injection site reactions
- Flushing
- Headaches
- Mild nausea
- Dizziness
Where to Buy Sermorelin
1 option across 1 vendor · Sorted cheapest first · All include direct product link
From
$34.99
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Storage & Reconstitution Guide
Storage Temperature
-20°C lyophilized, 4°C reconstituted
24 months (lyophilized), 28 days (reconstituted)
Reconstitution Solvent
Bacteriostatic water (BAC water)
Swirl gently — do not shake or vortex
Handling Notes
Protect lyophilized peptide from moisture and light. Once reconstituted, keep refrigerated. Discard if solution becomes cloudy or discolored. Use insulin syringe for precise dosing.
Step-by-Step Reconstitution
Gather supplies
BAC water, insulin syringe, alcohol swabs, vial
Disinfect tops
Swab rubber stoppers of both vials with alcohol
Draw BAC water
Pull desired mL of BAC water into syringe
Inject slowly
Inject BAC water down the side of the peptide vial, swirl gently to dissolve
Molecular Structure
- CAS Number
- 86168-78-7
- PubChem CID
- 16132413
- Molecular Weight
- 3,357.9 Da
- Mol. Formula
- C149H246N44O42S
- Amino Acids
- 29-AA peptide
- Wikipedia
- View article
Research Protocol
- Dose Range
- 0.2–0.3 mg
- Frequency
- Once daily at bedtime
- Cycle
- 3-6 months
- Half-Life
- 10-20 minutes
- Routes
- subcutaneous injection
- Notes
- Best administered at night to align with natural GH pulsatility.
Legal & Regulatory Status
Sold for research purposes only. Not for human use. Laws vary by country.
Commonly Stacked With
View all peptide stacks →External Resources
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Modified GRF 1-29
A synthetic 29-amino acid GHRH analog with 4 amino acid substitutions that improve stability and receptor affinity compared to Sermorelin. Unlike CJC-1295 DAC, it has no Drug Affinity Complex, giving it a short 30-minute half-life that mimics the body's natural pulsatile GHRH secretion when co-administered with a GHRP.
FST-344
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