Ipamorelin vs Sermorelin: Which GH Peptide Is Better?
Side-by-side comparison of ipamorelin and sermorelin for growth hormone stimulation. Selectivity, potency, clinical evidence, and cost comparison.
Ipamorelin
Ipamorelin acetate
Research OnlySermorelin
GRF 1-29 NH2
PrescriptionIpamorelin
A selective growth hormone secretagogue and ghrelin mimetic that stimulates GH release without significantly elevating cortisol or prolactin. One of the cleanest and most widely used peptides for body recomposition.
Sermorelin
A 29-amino acid synthetic analog of endogenous GHRH that stimulates natural GH production. Clinically used for GH deficiency and widely used in anti-aging medicine as a safer alternative to exogenous HGH.
Common Questions
Q: Which raises GH more?
See the full comparison in our detailed guide.
Q: Which has fewer side effects?
See the full comparison in our detailed guide.
Q: Which is prescribed more often?
See the full comparison in our detailed guide.
Q: Can you stack them?
See the full comparison in our detailed guide.
Q: Which lasts longer?
See the full comparison in our detailed guide.
Our Verdict
Winner: Ipamorelin (for selectivity)
Ipamorelin is more selective — it raises GH without significantly increasing cortisol, prolactin, or ACTH, making it safer for extended use. Sermorelin is more established clinically (FDA-approved for GH deficiency in children) and may produce slightly more robust GH elevation at equivalent doses. For most research protocols, ipamorelin is preferred; sermorelin is a strong alternative with a longer prescription history.