Sermorelin vs Tesamorelin: GHRH Analog Comparison
Comparing sermorelin and tesamorelin — two GHRH analogs for growth hormone stimulation. Which is more potent? Which is FDA-approved? What are the key differences?
Sermorelin
GRF 1-29 NH2
PrescriptionTesamorelin
Egrifta
FDA ApprovedSermorelin
A 29-amino acid synthetic analog of endogenous GHRH that stimulates natural GH production. Clinically used for GH deficiency and widely used in anti-aging medicine as a safer alternative to exogenous HGH.
Tesamorelin
An FDA-approved synthetic GHRH analog originally developed to treat HIV-associated lipodystrophy. Highly effective at reducing visceral adipose tissue.
Common Questions
Q: Which is more potent?
See the full comparison in our detailed guide.
Q: Which is FDA-approved?
See the full comparison in our detailed guide.
Q: Which reduces visceral fat more?
See the full comparison in our detailed guide.
Q: Which is better for GH deficiency?
See the full comparison in our detailed guide.
Q: What is the dosing difference?
See the full comparison in our detailed guide.
Our Verdict
Winner: Tesamorelin (for potency); Sermorelin (for availability)
Tesamorelin is FDA-approved for HIV-associated lipodystrophy and has robust Phase 3 clinical data for visceral fat reduction. It is the more potent GHRH analog. Sermorelin has a longer clinical history in GH deficiency management and is more widely prescribed by anti-aging physicians. Sermorelin is generally less expensive and more accessible from compounding pharmacies.