BAM15
Also known as: BAM 15 · Mitochondrial Uncoupler BAM15
A selective mitochondrial uncoupler that increases energy expenditure by diverting the proton gradient from ATP synthesis to heat production. In mouse models, BAM15 reversed diet-induced obesity and insulin resistance without increasing body temperature, heart rate, or affecting the plasma membrane — overcoming the critical safety limitations of earlier uncouplers like DNP.
Mechanism of Action
BAM15 is a protonophoric compound that selectively permeabilizes the inner mitochondrial membrane to protons, uncoupling the electron transport chain from ATP synthase. This forces mitochondria to burn more fuel (fat) to maintain the membrane potential, dramatically increasing metabolic rate. Crucially, its bulky structure prevents it from crossing the plasma membrane, making it organ-selective and avoiding the hyperthermia that makes DNP dangerous.
Benefits
- Reverses diet-induced obesity in mouse models
- Increases resting metabolic rate without hyperthermia
- Improves insulin sensitivity and glucose metabolism
- Does not increase body temperature (unlike DNP)
- No effect on heart rate at therapeutic doses
- Prevents mitochondrial membrane-selective uncoupling
- May have anti-cancer metabolic effects
Side Effects & Risks
- Limited human data — primarily mouse models
- Theoretical hyperthermia risk at high doses
- GI discomfort possible
- Not cleared for human use
Where to Buy BAM15
3 options across 3 vendors · Sorted cheapest first · All include direct product link
From
$125.00
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Storage & Reconstitution Guide
Storage Temperature
-20°C (lyophilized)
24 months (lyophilized), 28 days (reconstituted)
Reconstitution Solvent
Bacteriostatic water (BAC water)
Swirl gently — do not shake or vortex
Handling Notes
Protect lyophilized peptide from moisture and light. Once reconstituted, keep refrigerated. Discard if solution becomes cloudy or discolored. Use insulin syringe for precise dosing.
Step-by-Step Reconstitution
Gather supplies
BAC water, insulin syringe, alcohol swabs, vial
Disinfect tops
Swab rubber stoppers of both vials with alcohol
Draw BAC water
Pull desired mL of BAC water into syringe
Inject slowly
Inject BAC water down the side of the peptide vial, swirl gently to dissolve
Preclinical Research & Reviews1
BAM15-mediated mitochondrial uncoupling protects against obesity without hyperthermia
BAM15 prevented and reversed diet-induced obesity in mice without increasing body temperature or heart rate — overcoming the key safety limitations of earlier mitochondrial uncouplers like DNP.
Result
Prevented and reversed diet-induced obesity
Safety
No hyperthermia, no heart rate increase, plasma membrane sparing
Mechanism
Selective inner mitochondrial membrane proton transport
Research Protocol
- Dose Range
- 5–20 mg/kg/kg
- Frequency
- Once daily oral
- Cycle
- 4-8 weeks
- Half-Life
- Unknown
- Routes
- oral
- Notes
- Mouse studies used 5-20mg/kg. Human dose not established. Research compound only — significant caution warranted.
Legal & Regulatory Status
Sold for research purposes only. Not for human use. Laws vary by country.
Commonly Stacked With
View all peptide stacks →External Resources
Chemical Properties
- CAS Number
- 1429651-50-2
- Mol. Weight
- 357.4 Da
- Formula
- C13H10F3N3O4S
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