L-Glutathione
Also known as: GSH · Reduced glutathione · gamma-L-Glutamyl-L-cysteinyl-glycine
The body's master antioxidant and a tripeptide (Glu-Cys-Gly) found in virtually every cell. Injectable and IV glutathione dramatically raises systemic levels for anti-aging, skin brightening, neuroprotection, liver detoxification, and chronic disease management. Oral bioavailability is poor; injectable forms bypass absorption limitations.
What is L-Glutathione? The body's master antioxidant and a tripeptide (Glu-Cys-Gly) found in virtually every cell. Injectable and IV glutathione dramatically raises systemic levels for anti-aging, skin brightening, neuroprotection, liver detoxification, and chronic disease management. Oral bioavailability is poor; injectable forms bypass absorption limitations.
How does L-Glutathione work? Glutathione neutralizes reactive oxygen species (ROS) directly, regenerates vitamins C and E, and is required for Phase II hepatic detoxification via glutathione-S-transferase (GST). It also protects mitochondria, reduces inflammation via NF-kB pathway, and inhibits melanin synthesis (skin brightening mechanism). Direct injection bypasses the poor oral absorption that limits oral glutathione supplementation.
Benefits of L-Glutathione: Potent master antioxidant neutralizing ROS and free radicals; Liver detoxification (Phase II conjugation); Skin brightening via melanin synthesis inhibition; Neuroprotection in Parkinson disease models; Immune system enhancement; Anti-aging via mitochondrial protection; Heavy metal chelation; Reduces oxidative stress in chronic disease
L-Glutathione dosage: IV drip: 600-2400mg in 100-250mL saline over 30-60 min. SubQ: 600mg 3x/week. Oral liposomal: 250-500mg daily.
Research status: Research Only
Source: PeptideWiki — https://www.peptide-wiki.net/peptides/l-glutathione
Mechanism of Action
Glutathione neutralizes reactive oxygen species (ROS) directly, regenerates vitamins C and E, and is required for Phase II hepatic detoxification via glutathione-S-transferase (GST). It also protects mitochondria, reduces inflammation via NF-kB pathway, and inhibits melanin synthesis (skin brightening mechanism). Direct injection bypasses the poor oral absorption that limits oral glutathione supplementation.
Benefits
- Potent master antioxidant neutralizing ROS and free radicals
- Liver detoxification (Phase II conjugation)
- Skin brightening via melanin synthesis inhibition
- Neuroprotection in Parkinson disease models
- Immune system enhancement
- Anti-aging via mitochondrial protection
- Heavy metal chelation
- Reduces oxidative stress in chronic disease
Side Effects & Risks
- IV: flushing nausea if infused too rapidly
- High doses may cause zinc depletion
- Oral form largely ineffective (use sublingual or liposomal)
Where to Buy L-Glutathione
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Storage & Reconstitution Guide
Storage Temperature
-20°C (lyophilized)
24 months (lyophilized), 28 days (reconstituted)
Reconstitution Solvent
Bacteriostatic water (BAC water)
Swirl gently — do not shake or vortex
Handling Notes
Protect lyophilized peptide from moisture and light. Once reconstituted, keep refrigerated. Discard if solution becomes cloudy or discolored. Use insulin syringe for precise dosing.
Step-by-Step Reconstitution
Gather supplies
BAC water, insulin syringe, alcohol swabs, vial
Disinfect tops
Swab rubber stoppers of both vials with alcohol
Draw BAC water
Pull desired mL of BAC water into syringe
Inject slowly
Inject BAC water down the side of the peptide vial, swirl gently to dissolve
Preclinical Research & Reviews1
Glutathione: A key immune cell nutrient that protects against inflammation
Review confirming IV glutathione provides far superior bioavailability vs oral. GSH decline with age correlates directly with oxidative stress and immune dysfunction.
Key Finding
GSH decline with age correlates with oxidative stress and immune decline
Applications
Anti-aging, neuroprotection, liver detox, skin brightening
Bioavailability
IV/injectable far superior to oral forms
Molecular Structure
- CAS Number
- 70-18-8
- PubChem CID
- 124886
- Molecular Weight
- 307.32 Da
- Mol. Formula
- C10H17N3O6S
- Amino Acids
- 3-AA peptide
- Wikipedia
- View article
Research Protocol
- Dose Range
- 600–2400 mg
- Frequency
- 2-3x per week IV or daily SubQ
- Cycle
- Ongoing
- Routes
- intravenous injectionsubcutaneous injectionoral
- Notes
- IV drip: 600-2400mg in 100-250mL saline over 30-60 min. SubQ: 600mg 3x/week. Oral liposomal: 250-500mg daily.
Legal & Regulatory Status
Sold for research purposes only. Not for human use. Laws vary by country.
Commonly Stacked With
View all peptide stacks →External Resources
PeptideWiki Research Team
Evidence-based research data sourced from PubMed and ClinicalTrials.gov · Last updated: February 25, 2026
Frequently Asked Questions About L-Glutathione
What is L-Glutathione?▾
The body's master antioxidant and a tripeptide (Glu-Cys-Gly) found in virtually every cell. Injectable and IV glutathione dramatically raises systemic levels for anti-aging, skin brightening, neuroprotection, liver detoxification, and chronic disease management. Oral bioavailability is poor; injectable forms bypass absorption limitations.
What are the benefits of L-Glutathione?▾
Potent master antioxidant neutralizing ROS and free radicals
What are the benefits of L-Glutathione?▾
Liver detoxification (Phase II conjugation)
What are the side effects of L-Glutathione?▾
IV: flushing nausea if infused too rapidly
What is the recommended dosage for L-Glutathione?▾
IV drip: 600-2400mg in 100-250mL saline over 30-60 min. SubQ: 600mg 3x/week. Oral liposomal: 250-500mg daily.
How long should a L-Glutathione cycle last?▾
Ongoing
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