NAD+ (Nicotinamide Adenine Dinucleotide)
Also known as: NAD+ · NAD · Nicotinamide adenine dinucleotide
A coenzyme found in all living cells, essential for cellular energy production, DNA repair, and sirtuin activation. NAD+ levels decline with age by up to 50%, contributing to metabolic dysfunction and aging. Injectable NAD+ therapy is studied for anti-aging, addiction treatment, and neurological disease.
What is NAD+ (Nicotinamide Adenine Dinucleotide)? A coenzyme found in all living cells, essential for cellular energy production, DNA repair, and sirtuin activation. NAD+ levels decline with age by up to 50%, contributing to metabolic dysfunction and aging. Injectable NAD+ therapy is studied for anti-aging, addiction treatment, and neurological disease.
How does NAD+ (Nicotinamide Adenine Dinucleotide) work? NAD+ is a cofactor for over 400 enzymatic reactions including the electron transport chain (energy production), sirtuins (gene expression and longevity), PARP enzymes (DNA repair), and CD38 (immune function). Supplementing NAD+ directly restores these functions that decline with age.
Benefits of NAD+ (Nicotinamide Adenine Dinucleotide): Directly restores cellular NAD+ levels; Activates sirtuins (SIRT1-7) for longevity pathways; DNA repair pathway support (PARP enzymes); Enhanced mitochondrial function and energy production; Studied for addiction treatment (IV NAD+ protocols); Neuroprotection and cognitive support; Anti-aging via multiple pathways
NAD+ (Nicotinamide Adenine Dinucleotide) dosage: IV NAD+ is most effective: 250-1000mg over 2-4 hours. Sublingual or SubQ injections also used. NMN/NR are precursors and alternatives.
NAD+ (Nicotinamide Adenine Dinucleotide) half-life: Short (degraded rapidly)
Research status: Research Only
Source: PeptideWiki — https://www.peptide-wiki.net/peptides/nad-plus
Mechanism of Action
NAD+ is a cofactor for over 400 enzymatic reactions including the electron transport chain (energy production), sirtuins (gene expression and longevity), PARP enzymes (DNA repair), and CD38 (immune function). Supplementing NAD+ directly restores these functions that decline with age.
Benefits
- Directly restores cellular NAD+ levels
- Activates sirtuins (SIRT1-7) for longevity pathways
- DNA repair pathway support (PARP enzymes)
- Enhanced mitochondrial function and energy production
- Studied for addiction treatment (IV NAD+ protocols)
- Neuroprotection and cognitive support
- Anti-aging via multiple pathways
Side Effects & Risks
- IV infusions can cause flushing, nausea, chest discomfort
- Oral NAD+ has poor bioavailability
- Side effects reduced by slow infusion rate
- Potential headache
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Storage & Reconstitution Guide
Storage Temperature
-20°C lyophilized (injectable)
24 months (lyophilized), 28 days (reconstituted)
Reconstitution Solvent
Sterile water for IV; saline for subcutaneous; oral needs no reconstitution
Swirl gently — do not shake or vortex
Handling Notes
Protect lyophilized peptide from moisture and light. Once reconstituted, keep refrigerated. Discard if solution becomes cloudy or discolored. Use insulin syringe for precise dosing.
Step-by-Step Reconstitution
Gather supplies
BAC water, insulin syringe, alcohol swabs, vial
Disinfect tops
Swab rubber stoppers of both vials with alcohol
Draw BAC water
Pull desired mL of BAC water into syringe
Inject slowly
Inject BAC water down the side of the peptide vial, swirl gently to dissolve
Research Protocol
- Dose Range
- 250–1000 mg
- Frequency
- IV: once daily 3-10 day course. Sublingual/SubQ: daily.
- Cycle
- 3-10 day IV course, then maintenance
- Half-Life
- Short (degraded rapidly)
- Routes
- intravenous injectionsubcutaneous injectionoral
- Notes
- IV NAD+ is most effective: 250-1000mg over 2-4 hours. Sublingual or SubQ injections also used. NMN/NR are precursors and alternatives.
Legal & Regulatory Status
Sold for research purposes only. Not for human use. Laws vary by country.
Commonly Stacked With
View all peptide stacks →External Resources
PeptideWiki Research Team
Evidence-based research data sourced from PubMed and ClinicalTrials.gov · Last updated: February 25, 2026
Frequently Asked Questions About NAD+ (Nicotinamide Adenine Dinucleotide)
What is NAD+ (Nicotinamide Adenine Dinucleotide)?▾
A coenzyme found in all living cells, essential for cellular energy production, DNA repair, and sirtuin activation. NAD+ levels decline with age by up to 50%, contributing to metabolic dysfunction and aging. Injectable NAD+ therapy is studied for anti-aging, addiction treatment, and neurological disease.
What are the benefits of NAD+ (Nicotinamide Adenine Dinucleotide)?▾
Directly restores cellular NAD+ levels
What are the benefits of NAD+ (Nicotinamide Adenine Dinucleotide)?▾
Activates sirtuins (SIRT1-7) for longevity pathways
What are the side effects of NAD+ (Nicotinamide Adenine Dinucleotide)?▾
IV infusions can cause flushing, nausea, chest discomfort
What is the recommended dosage for NAD+ (Nicotinamide Adenine Dinucleotide)?▾
IV NAD+ is most effective: 250-1000mg over 2-4 hours. Sublingual or SubQ injections also used. NMN/NR are precursors and alternatives.
How long should a NAD+ (Nicotinamide Adenine Dinucleotide) cycle last?▾
3-10 day IV course, then maintenance
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