Mazdutide
Also known as: Peptide-M · IBI362 · GLP-1/Gcg receptor agonist
A GLP-1 and glucagon receptor co-agonist developed by Innovent Biologics. In Phase 3 clinical trials in China with strong efficacy data. Shows comparable weight loss to tirzepatide while also reducing liver fat. Also studied for type 2 diabetes management.
Mechanism of Action
Mazdutide activates both GLP-1R and glucagon receptor with a balanced agonism ratio. GLP-1R activation drives appetite suppression and glucose control; glucagon receptor activation increases resting energy expenditure and promotes hepatic lipid oxidation. Together these pathways produce robust weight loss with additional metabolic benefits.
Benefits
- Robust weight loss: 12-15% body weight in Phase 3 trials
- Dual GLP-1 and glucagon receptor activation
- Significant reduction in liver fat (NASH application)
- Glucose control improvement
- Once-weekly dosing
- Strong Phase 3 data from Chinese clinical trials
Side Effects & Risks
- Nausea and vomiting
- GI side effects typical of GLP-1 class
- Phase 3 data primarily from Chinese population
Where to Buy Mazdutide
1 option across 1 vendor · Sorted cheapest first · All include direct product link
From
$249.99
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Storage & Reconstitution Guide
Storage Temperature
-20°C lyophilized, 4°C reconstituted
24 months (lyophilized), 28 days (reconstituted)
Reconstitution Solvent
Bacteriostatic water (BAC water)
Swirl gently — do not shake or vortex
Handling Notes
Protect lyophilized peptide from moisture and light. Once reconstituted, keep refrigerated. Discard if solution becomes cloudy or discolored. Use insulin syringe for precise dosing.
Step-by-Step Reconstitution
Gather supplies
BAC water, insulin syringe, alcohol swabs, vial
Disinfect tops
Swab rubber stoppers of both vials with alcohol
Draw BAC water
Pull desired mL of BAC water into syringe
Inject slowly
Inject BAC water down the side of the peptide vial, swirl gently to dissolve
Research Protocol
- Dose Range
- 2–6 mg
- Frequency
- Once weekly subcutaneous injection
- Cycle
- Ongoing / chronic
- Routes
- subcutaneous injection
- Notes
- Phase 3 doses used: 3-9mg/week. Titration protocol recommended. Not yet FDA approved.
Legal & Regulatory Status
Sold for research purposes only. Not for human use. Laws vary by country.
Commonly Stacked With
View all peptide stacks →External Resources
Chemical Properties
- Mol. Weight
- ~4,700 Da
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