Survodutide
Also known as: Peptide-SU · BI 456906 · GLP-1/glucagon dual agonist
A dual GLP-1 and glucagon receptor agonist developed by Boehringer Ingelheim. Phase 2b trials showed superior weight loss to semaglutide at 6 months. Also being studied for NASH/MASH (metabolic steatohepatitis), a liver disease with limited treatment options.
Mechanism of Action
Survodutide simultaneously activates GLP-1 receptors (appetite suppression, incretin effect) and glucagon receptors (increased energy expenditure, hepatic fat mobilization). The glucagon agonism component particularly drives liver fat reduction, making survodutide uniquely effective for metabolic liver disease in addition to obesity.
Benefits
- Superior weight loss to semaglutide in Phase 2b (up to 19% at 46 weeks)
- Unique hepatic fat reduction via glucagon agonism (NASH/MASH)
- Once-weekly dosing
- Both GLP-1 and glucagon receptor activation
- Significant improvement in liver disease biomarkers
- In Phase 3 trials for MASH and obesity
Side Effects & Risks
- Nausea and vomiting (GLP-1 class effects)
- Diarrhea
- Currently Phase 2/3 — long-term safety profile still being established
Where to Buy Survodutide
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Storage & Reconstitution Guide
Storage Temperature
-20°C lyophilized, 4°C reconstituted
24 months (lyophilized), 28 days (reconstituted)
Reconstitution Solvent
Bacteriostatic water (BAC water)
Swirl gently — do not shake or vortex
Handling Notes
Protect lyophilized peptide from moisture and light. Once reconstituted, keep refrigerated. Discard if solution becomes cloudy or discolored. Use insulin syringe for precise dosing.
Step-by-Step Reconstitution
Gather supplies
BAC water, insulin syringe, alcohol swabs, vial
Disinfect tops
Swab rubber stoppers of both vials with alcohol
Draw BAC water
Pull desired mL of BAC water into syringe
Inject slowly
Inject BAC water down the side of the peptide vial, swirl gently to dissolve
Research Protocol
- Dose Range
- 1.2–4.8 mg
- Frequency
- Once weekly subcutaneous injection
- Cycle
- Ongoing / chronic
- Routes
- subcutaneous injection
- Notes
- Phase 2b dose range: 1.2-6.0mg/week. Titration recommended. Not yet FDA approved — Phase 3 trials ongoing as of 2025.
Legal & Regulatory Status
Sold for research purposes only. Not for human use. Laws vary by country.
Commonly Stacked With
View all peptide stacks →External Resources
Chemical Properties
- CAS Number
- 2059046-38-3
- Mol. Weight
- ~4,600 Da
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