SNAP-8
Also known as: Acetyl Glutamyl Heptapeptide-1 · Acetyl Octapeptide-3 · Leuphasyl-Acetyl Tetrapeptide-2
A synthetic octapeptide designed to mimic the N-terminal end of the SNAP-25 protein, competing with its binding site in the SNARE complex. Inhibits neuromuscular vesicle fusion at the dermal-epidermal junction, reducing expression-line depth and preventing dynamic wrinkle formation. Often called the "topical alternative to Botox."
What is SNAP-8? A synthetic octapeptide designed to mimic the N-terminal end of the SNAP-25 protein, competing with its binding site in the SNARE complex. Inhibits neuromuscular vesicle fusion at the dermal-epidermal junction, reducing expression-line depth and preventing dynamic wrinkle formation. Often called the "topical alternative to Botox."
How does SNAP-8 work? SNAP-8 interferes with SNARE (Soluble NSF Attachment Protein Receptor) complex formation by competing with SNAP-25 at the neuronal membrane level. This reduces the release of catecholamines from synaptic vesicles at the neuromuscular junction in the skin, decreasing the frequency of muscle contractions responsible for dynamic wrinkles. 2x more concentrated than the similar Argireline peptide.
Benefits of SNAP-8: Reduces expression-line depth and wrinkle severity; Interferes with SNARE complex neuromuscular signaling; "Topical Botox" mechanism without injections; Reduces crow's feet, forehead lines, and glabellar wrinkles; Suitable for inclusion in topical formulations; Complementary to standard anti-aging peptides; Well tolerated topically
SNAP-8 dosage: Topical concentration: 3-10% in final formulation. For research: reconstituted in carrier solution. No established injectable protocol.
Research status: Research Only
Source: PeptideWiki — https://www.peptide-wiki.net/peptides/snap-8
Mechanism of Action
SNAP-8 interferes with SNARE (Soluble NSF Attachment Protein Receptor) complex formation by competing with SNAP-25 at the neuronal membrane level. This reduces the release of catecholamines from synaptic vesicles at the neuromuscular junction in the skin, decreasing the frequency of muscle contractions responsible for dynamic wrinkles. 2x more concentrated than the similar Argireline peptide.
Benefits
- Reduces expression-line depth and wrinkle severity
- Interferes with SNARE complex neuromuscular signaling
- "Topical Botox" mechanism without injections
- Reduces crow's feet, forehead lines, and glabellar wrinkles
- Suitable for inclusion in topical formulations
- Complementary to standard anti-aging peptides
- Well tolerated topically
Side Effects & Risks
- Primarily cosmetic/topical use — injectable research limited
- Mild skin irritation possible
- Efficacy varies by formulation concentration
Where to Buy SNAP-8
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Storage & Reconstitution Guide
Storage Temperature
-20°C (lyophilized)
24 months (lyophilized), 28 days (reconstituted)
Reconstitution Solvent
Bacteriostatic water (BAC water)
Swirl gently — do not shake or vortex
Handling Notes
Protect lyophilized peptide from moisture and light. Once reconstituted, keep refrigerated. Discard if solution becomes cloudy or discolored. Use insulin syringe for precise dosing.
Step-by-Step Reconstitution
Gather supplies
BAC water, insulin syringe, alcohol swabs, vial
Disinfect tops
Swab rubber stoppers of both vials with alcohol
Draw BAC water
Pull desired mL of BAC water into syringe
Inject slowly
Inject BAC water down the side of the peptide vial, swirl gently to dissolve
Molecular Structure
- CAS Number
- 868844-74-0
- PubChem CID
- 44574665
- Molecular Weight
- 1,075.1 Da
- Mol. Formula
- C41H70N16O16S
- Amino Acids
- 8-AA peptide
Research Protocol
- Frequency
- Topical: 1-2x daily to affected areas
- Cycle
- Ongoing (topical)
- Routes
- topical
- Notes
- Topical concentration: 3-10% in final formulation. For research: reconstituted in carrier solution. No established injectable protocol.
Legal & Regulatory Status
Sold for research purposes only. Not for human use. Laws vary by country.
Commonly Stacked With
View all peptide stacks →External Resources
PeptideWiki Research Team
Evidence-based research data sourced from PubMed and ClinicalTrials.gov · Last updated: February 25, 2026
Frequently Asked Questions About SNAP-8
What is SNAP-8?▾
A synthetic octapeptide designed to mimic the N-terminal end of the SNAP-25 protein, competing with its binding site in the SNARE complex. Inhibits neuromuscular vesicle fusion at the dermal-epidermal junction, reducing expression-line depth and preventing dynamic wrinkle formation. Often called the "topical alternative to Botox."
What are the benefits of SNAP-8?▾
Reduces expression-line depth and wrinkle severity
What are the benefits of SNAP-8?▾
Interferes with SNARE complex neuromuscular signaling
What are the side effects of SNAP-8?▾
Primarily cosmetic/topical use — injectable research limited
What is the recommended dosage for SNAP-8?▾
Topical concentration: 3-10% in final formulation. For research: reconstituted in carrier solution. No established injectable protocol.
How long should a SNAP-8 cycle last?▾
Ongoing (topical)
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