HGH Fragment 176-191
Also known as: GH Fragment · HGH Frag 176-191 · GH Frag 176-191
The original C-terminal fragment of human growth hormone spanning amino acids 176-191. Contains the fat-burning region of HGH without the growth-promoting (IGF-1-stimulating) region. Slightly different structure from AOD-9604 but essentially the same compound; AOD-9604 is a modified version with a disulfide bridge.
What is HGH Fragment 176-191? The original C-terminal fragment of human growth hormone spanning amino acids 176-191. Contains the fat-burning region of HGH without the growth-promoting (IGF-1-stimulating) region. Slightly different structure from AOD-9604 but essentially the same compound; AOD-9604 is a modified version with a disulfide bridge.
How does HGH Fragment 176-191 work? HGH Fragment 176-191 directly mimics the lipolytic action of full HGH at the adipocyte level: it stimulates hormone-sensitive lipase (HSL) to break down stored fat (lipolysis) and suppresses the activity of lipoprotein lipase (LPL) which stores fat. Critically, it does not stimulate IGF-1, does not affect insulin, and does not promote long-bone growth.
Benefits of HGH Fragment 176-191: Pure fat-burning without growth or IGF-1 effects; Stimulates lipolysis (fat breakdown); Inhibits lipogenesis (fat storage); Cartilage healing properties also noted; No glucose dysregulation; Reduces obesity in multiple animal models
HGH Fragment 176-191 dosage: Best on empty stomach (enhances lipolytic effect). Morning fasted injection is most common. 6mg vial size typical.
HGH Fragment 176-191 half-life: Short (~30 min)
Research status: Research Only
Source: PeptideWiki — https://www.peptide-wiki.net/peptides/hgh-fragment-176-191
Mechanism of Action
HGH Fragment 176-191 directly mimics the lipolytic action of full HGH at the adipocyte level: it stimulates hormone-sensitive lipase (HSL) to break down stored fat (lipolysis) and suppresses the activity of lipoprotein lipase (LPL) which stores fat. Critically, it does not stimulate IGF-1, does not affect insulin, and does not promote long-bone growth.
Benefits
- Pure fat-burning without growth or IGF-1 effects
- Stimulates lipolysis (fat breakdown)
- Inhibits lipogenesis (fat storage)
- Cartilage healing properties also noted
- No glucose dysregulation
- Reduces obesity in multiple animal models
Side Effects & Risks
- Minor headaches
- Facial flushing
- Injection site swelling
- Low blood sugar if fasted (rare)
Where to Buy HGH Fragment 176-191
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Storage & Reconstitution Guide
Storage Temperature
-20°C (lyophilized)
24 months (lyophilized), 28 days (reconstituted)
Reconstitution Solvent
Bacteriostatic water (BAC water)
Swirl gently — do not shake or vortex
Handling Notes
Protect lyophilized peptide from moisture and light. Once reconstituted, keep refrigerated. Discard if solution becomes cloudy or discolored. Use insulin syringe for precise dosing.
Step-by-Step Reconstitution
Gather supplies
BAC water, insulin syringe, alcohol swabs, vial
Disinfect tops
Swab rubber stoppers of both vials with alcohol
Draw BAC water
Pull desired mL of BAC water into syringe
Inject slowly
Inject BAC water down the side of the peptide vial, swirl gently to dissolve
Research Protocol
- Dose Range
- 250–500 mcg
- Frequency
- Once or twice daily, fasted state
- Cycle
- 20-30 days
- Half-Life
- Short (~30 min)
- Routes
- subcutaneous injection
- Notes
- Best on empty stomach (enhances lipolytic effect). Morning fasted injection is most common. 6mg vial size typical.
Legal & Regulatory Status
Sold for research purposes only. Not for human use. Laws vary by country.
Commonly Stacked With
View all peptide stacks →External Resources
Chemical Properties
- CAS Number
- 66004-57-7
- Mol. Weight
- 1,817.0 Da
- Formula
- C78H123N23O23S2
PeptideWiki Research Team
Evidence-based research data sourced from PubMed and ClinicalTrials.gov · Last updated: February 25, 2026
Frequently Asked Questions About HGH Fragment 176-191
What is HGH Fragment 176-191?▾
The original C-terminal fragment of human growth hormone spanning amino acids 176-191. Contains the fat-burning region of HGH without the growth-promoting (IGF-1-stimulating) region. Slightly different structure from AOD-9604 but essentially the same compound; AOD-9604 is a modified version with a disulfide bridge.
What are the benefits of HGH Fragment 176-191?▾
Pure fat-burning without growth or IGF-1 effects
What are the benefits of HGH Fragment 176-191?▾
Stimulates lipolysis (fat breakdown)
What are the side effects of HGH Fragment 176-191?▾
Minor headaches
What is the recommended dosage for HGH Fragment 176-191?▾
Best on empty stomach (enhances lipolytic effect). Morning fasted injection is most common. 6mg vial size typical.
How long should a HGH Fragment 176-191 cycle last?▾
20-30 days
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