NMN (Nicotinamide Mononucleotide)
Also known as: NMN · Nicotinamide mononucleotide · NAD+ precursor
A direct precursor to NAD+ that is more bioavailable than NAD+ itself. NMN is converted to NAD+ via the NMN/NR pathway in cells. Extensively studied in David Sinclair's lab as a longevity compound.
What is NMN (Nicotinamide Mononucleotide)? A direct precursor to NAD+ that is more bioavailable than NAD+ itself. NMN is converted to NAD+ via the NMN/NR pathway in cells. Extensively studied in David Sinclair's lab as a longevity compound.
How does NMN (Nicotinamide Mononucleotide) work? NMN is phosphorylated to NMN-monophosphate and then converted to NAD+ by NMN adenylyltransferase (NMNAT). Because NMN can enter cells more efficiently than NAD+, it is a more practical way to raise intracellular NAD+ levels. It activates the same sirtuins, DNA repair enzymes, and mitochondrial pathways as NAD+ supplementation.
Benefits of NMN (Nicotinamide Mononucleotide): Raises cellular NAD+ levels efficiently; Activates sirtuins for longevity signaling; Improves insulin sensitivity and metabolic health; Enhances mitochondrial function; DNA repair support; Anti-aging: reverses vascular aging in mice; Generally well tolerated orally
NMN (Nicotinamide Mononucleotide) dosage: Standard dose: 500mg/day. Sublingual may have better bioavailability. Take in the morning for circadian rhythm alignment.
NMN (Nicotinamide Mononucleotide) half-life: 2-3 hours
Research status: Research Only
Source: PeptideWiki — https://www.peptide-wiki.net/peptides/nmn
Mechanism of Action
NMN is phosphorylated to NMN-monophosphate and then converted to NAD+ by NMN adenylyltransferase (NMNAT). Because NMN can enter cells more efficiently than NAD+, it is a more practical way to raise intracellular NAD+ levels. It activates the same sirtuins, DNA repair enzymes, and mitochondrial pathways as NAD+ supplementation.
Benefits
- Raises cellular NAD+ levels efficiently
- Activates sirtuins for longevity signaling
- Improves insulin sensitivity and metabolic health
- Enhances mitochondrial function
- DNA repair support
- Anti-aging: reverses vascular aging in mice
- Generally well tolerated orally
Side Effects & Risks
- Mild nausea at high doses
- Flushing (less than niacin)
- Potential interactions with cancer treatments
- Long-term human data still accumulating
Where to Buy NMN (Nicotinamide Mononucleotide)
1 option across 1 vendor · Sorted cheapest first · All include direct product link
From
$48.00
All links are affiliate links — PeptideWiki earns a commission at no extra cost to you. Coupon codes apply at checkout. Prices and availability may change. Always verify COA before purchasing.
Storage & Reconstitution Guide
Storage Temperature
15°C or below, away from light
24 months (lyophilized), 28 days (reconstituted)
Reconstitution Solvent
Oral capsule — no reconstitution; dissolve in water for sublingual
Swirl gently — do not shake or vortex
Handling Notes
Protect lyophilized peptide from moisture and light. Once reconstituted, keep refrigerated. Discard if solution becomes cloudy or discolored. Use insulin syringe for precise dosing.
Step-by-Step Reconstitution
Gather supplies
BAC water, insulin syringe, alcohol swabs, vial
Disinfect tops
Swab rubber stoppers of both vials with alcohol
Draw BAC water
Pull desired mL of BAC water into syringe
Inject slowly
Inject BAC water down the side of the peptide vial, swirl gently to dissolve
Preclinical Research & Reviews1
NMN supplementation increases NAD+ and reverses vascular aging in mice
NMN supplementation for 12 months reversed age-related vascular decline and increased muscle insulin sensitivity in aging mice.
Research Protocol
- Dose Range
- 250–1000 mg
- Frequency
- Once daily oral or sublingual
- Cycle
- Ongoing
- Half-Life
- 2-3 hours
- Routes
- oralsublingual
- Notes
- Standard dose: 500mg/day. Sublingual may have better bioavailability. Take in the morning for circadian rhythm alignment.
Legal & Regulatory Status
Sold for research purposes only. Not for human use. Laws vary by country.
Commonly Stacked With
View all peptide stacks →External Resources
PeptideWiki Research Team
Evidence-based research data sourced from PubMed and ClinicalTrials.gov · Last updated: February 25, 2026
Frequently Asked Questions About NMN (Nicotinamide Mononucleotide)
What is NMN (Nicotinamide Mononucleotide)?▾
A direct precursor to NAD+ that is more bioavailable than NAD+ itself. NMN is converted to NAD+ via the NMN/NR pathway in cells. Extensively studied in David Sinclair's lab as a longevity compound.
What are the benefits of NMN (Nicotinamide Mononucleotide)?▾
Raises cellular NAD+ levels efficiently
What are the benefits of NMN (Nicotinamide Mononucleotide)?▾
Activates sirtuins for longevity signaling
What are the side effects of NMN (Nicotinamide Mononucleotide)?▾
Mild nausea at high doses
What is the recommended dosage for NMN (Nicotinamide Mononucleotide)?▾
Standard dose: 500mg/day. Sublingual may have better bioavailability. Take in the morning for circadian rhythm alignment.
How long should a NMN (Nicotinamide Mononucleotide) cycle last?▾
Ongoing
More Anti-Aging & Longevity Peptides
View all Anti-Aging & Longevity peptides →Livagen
KEDA tetrapeptide
A synthetic tetrapeptide (Lys-Glu-Asp-Ala) from the Khavinson bioregulator series that de-heterochromatinizes age-condensed chromatin in lymphocytes, restoring youthful gene expression patterns. Hepatoprotective and immunomodulatory. One of the most mechanistically unique anti-aging peptides — it directly reactivates genes silenced by chromatin condensation with age.
Thyreogen
Thyroid peptide bioregulator
A thyroid-targeting tetrapeptide bioregulator from the Khavinson series. Normalizes thyroid cell function, thyroid hormone synthesis, and thyroid morphology. Studied for hypothyroidism, autoimmune thyroiditis, and thyroid aging. One of the most widely used Khavinson organ bioregulators given the high prevalence of thyroid dysfunction.
Ventfort
Vascular wall peptide bioregulator
A peptide bioregulator targeting blood vessel walls from the Khavinson series. Normalizes vascular endothelial cell function, reduces oxidative damage to vessel walls, and improves microcirculation. Distinct from Vesugen (which is the synthetic tripeptide form) in being the natural extract-based vascular bioregulator complex.
Vilon
Lys-Glu
A synthetic dipeptide from the Khavinson bioregulator series. Primarily acts as a thymus and immune regulator with demonstrated anti-aging properties.