NMN (Nicotinamide Mononucleotide)
Also known as: NMN · Nicotinamide mononucleotide · NAD+ precursor
A direct precursor to NAD+ that is more bioavailable than NAD+ itself. NMN is converted to NAD+ via the NMN/NR pathway in cells. Extensively studied in David Sinclair's lab as a longevity compound.
Mechanism of Action
NMN is phosphorylated to NMN-monophosphate and then converted to NAD+ by NMN adenylyltransferase (NMNAT). Because NMN can enter cells more efficiently than NAD+, it is a more practical way to raise intracellular NAD+ levels. It activates the same sirtuins, DNA repair enzymes, and mitochondrial pathways as NAD+ supplementation.
Benefits
- Raises cellular NAD+ levels efficiently
- Activates sirtuins for longevity signaling
- Improves insulin sensitivity and metabolic health
- Enhances mitochondrial function
- DNA repair support
- Anti-aging: reverses vascular aging in mice
- Generally well tolerated orally
Side Effects & Risks
- Mild nausea at high doses
- Flushing (less than niacin)
- Potential interactions with cancer treatments
- Long-term human data still accumulating
Where to Buy NMN (Nicotinamide Mononucleotide)
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From
$48.00
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Storage & Reconstitution Guide
Storage Temperature
15°C or below, away from light
24 months (lyophilized), 28 days (reconstituted)
Reconstitution Solvent
Oral capsule — no reconstitution; dissolve in water for sublingual
Swirl gently — do not shake or vortex
Handling Notes
Protect lyophilized peptide from moisture and light. Once reconstituted, keep refrigerated. Discard if solution becomes cloudy or discolored. Use insulin syringe for precise dosing.
Step-by-Step Reconstitution
Gather supplies
BAC water, insulin syringe, alcohol swabs, vial
Disinfect tops
Swab rubber stoppers of both vials with alcohol
Draw BAC water
Pull desired mL of BAC water into syringe
Inject slowly
Inject BAC water down the side of the peptide vial, swirl gently to dissolve
Preclinical Research & Reviews1
NMN supplementation increases NAD+ and reverses vascular aging in mice
NMN supplementation for 12 months reversed age-related vascular decline and increased muscle insulin sensitivity in aging mice.
Research Protocol
- Dose Range
- 250–1000 mg
- Frequency
- Once daily oral or sublingual
- Cycle
- Ongoing
- Half-Life
- 2-3 hours
- Routes
- oralsublingual
- Notes
- Standard dose: 500mg/day. Sublingual may have better bioavailability. Take in the morning for circadian rhythm alignment.
Legal & Regulatory Status
Sold for research purposes only. Not for human use. Laws vary by country.
Commonly Stacked With
View all peptide stacks →External Resources
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